Sanchita Kar, Zannat Kawser, Sushmita Sridhar, Sharmin Aktar Mukta, Neamul Hasan, Abu Bakar Siddik, Mohammad Tanbir Habib, Damien M Slater, Ashlee M Earl, Colin J Worby, Kasrina Azad, S M Shamsuzzaman, Nusrat Noor Tanni, Raisa Tasnia Khan, Meherunnisa Moonmoon, Firdausi Qadri, Jason B Harris, Regina C LaRocque
{"title":"孟加拉国达卡粪便和水样本中抗碳青霉烯类肺炎克雷伯氏菌的高流行率。","authors":"Sanchita Kar, Zannat Kawser, Sushmita Sridhar, Sharmin Aktar Mukta, Neamul Hasan, Abu Bakar Siddik, Mohammad Tanbir Habib, Damien M Slater, Ashlee M Earl, Colin J Worby, Kasrina Azad, S M Shamsuzzaman, Nusrat Noor Tanni, Raisa Tasnia Khan, Meherunnisa Moonmoon, Firdausi Qadri, Jason B Harris, Regina C LaRocque","doi":"10.1093/ofid/ofae612","DOIUrl":null,"url":null,"abstract":"<p><p>We evaluated <i>Klebsiella pneumoniae</i> (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (<i>P</i> = .03, <i>t</i>-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"11 11","pages":"ofae612"},"PeriodicalIF":3.8000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11530955/pdf/","citationCount":"0","resultStr":"{\"title\":\"High Prevalence of Carbapenem-resistant <i>Klebsiella Pneumoniae</i> in Fecal and Water Samples in Dhaka, Bangladesh.\",\"authors\":\"Sanchita Kar, Zannat Kawser, Sushmita Sridhar, Sharmin Aktar Mukta, Neamul Hasan, Abu Bakar Siddik, Mohammad Tanbir Habib, Damien M Slater, Ashlee M Earl, Colin J Worby, Kasrina Azad, S M Shamsuzzaman, Nusrat Noor Tanni, Raisa Tasnia Khan, Meherunnisa Moonmoon, Firdausi Qadri, Jason B Harris, Regina C LaRocque\",\"doi\":\"10.1093/ofid/ofae612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We evaluated <i>Klebsiella pneumoniae</i> (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (<i>P</i> = .03, <i>t</i>-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.</p>\",\"PeriodicalId\":19517,\"journal\":{\"name\":\"Open Forum Infectious Diseases\",\"volume\":\"11 11\",\"pages\":\"ofae612\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11530955/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Forum Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ofid/ofae612\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofae612","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
High Prevalence of Carbapenem-resistant Klebsiella Pneumoniae in Fecal and Water Samples in Dhaka, Bangladesh.
We evaluated Klebsiella pneumoniae (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (P = .03, t-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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