美味喂食对雌雄大鼠吗啡条件性位置偏好的表达和恢复的影响

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Yonca Cam, Courtney G. Kocum, Tabitha K. Houska, Ella R. Konrad, Tim A. Schweizer, Matthew J. Will
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引用次数: 0

摘要

众所周知,许多环境因素对阿片类药物使用障碍(OUD)患者的康复和复发风险都有影响,但饮食因素的作用却相对较少。患有阿片类药物滥用症的患者会表现出不健康的饮食习惯,并对可口的 "垃圾食品 "产生强烈的渴望,但这种关系还没有得到很好的描述。本研究首先确定了获得适口食物对雌雄大鼠急性吗啡暴露条件奖赏特性表达的影响,从而开始研究这种关系。在所有大鼠建立吗啡条件性位置偏好(CPP)后,在弛张肌(Acb)内给予μ-阿片受体激动剂D-Ala2,NMe-Phe4,Glyol5-enkephalin(DAMGO)+20分钟无饮食(ND)或高脂肪(HF),以平衡的顺序评估吗啡CPP的表达。接下来,所有大鼠都接受了12次消退训练,然后在不进行任何处理的情况下首先评估CPP的表达,然后在反平衡的ND和HF处理后再次评估CPP的表达。结果显示,雌雄大鼠的吗啡 CPP 表达水平相似。对吗啡 CPP 表达的后续检查显示,与 ND 处理相比,HF 处理显著降低了雄性大鼠的吗啡 CPP 表达,但雌性大鼠没有降低。无论是 HF 还是 ND 处理,都不会导致雄性或雌性吗啡 CPP 在绝迹后恢复。总之,适口喂食对条件性药物寻求表达的影响可能具有性别特异性,并且在灭绝前更为敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Palatable feeding effects on expression and reinstatement of morphine conditioned place preference in male and female rats
While many environmental factors are known to play a factor in the recovery and risk of relapse for individuals with opioid use disorder (OUD), the role of diet has been relatively unexplored. Individuals with OUD demonstrate unhealthy diet choices with an exaggerated craving for palatable “junk food,” yet this relationship has not been well characterized. The present study begins to examine this relationship by first determining the influence of palatable food access on the expression of conditioned rewarding properties of acute morphine exposure in male and female rats. Following the establishment of morphine conditioned place preference (CPP) in all rats, morphine CPP expression was assessed following intra-accumbens (Acb) administration of the µ-opioid receptor agonist D-Ala2,NMe-Phe4,Glyol5-enkephalin (DAMGO) + 20 min access to no diet (ND) or high-fat (HF), in counter-balanced order. Next, all rats received 12 sessions of extinction training before CPP expression was first assessed following no treatment, then again following counter-balanced ND and HF treatments. The results showed that both male and female rats expressed similar levels of morphine CPP. Subsequent examination of morphine CPP expression revealed that HF treatment significantly reduced morphine CPP expression in males, but not females, compared to ND treatment. Neither HF or ND treatment produced morphine CPP reinstatement in either males or females following extinction. In summary, the impact of palatable feeding on the expression of conditioned drug seeking may be sex-specific and more sensitive prior to extinction.
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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