Ersin Kasım Ulusoy, Döndü Melek Ulusoy, Mehmet Fatih Göl, Ayşe Çiçek, Turgut Tursem Tokmak
{"title":"阿尔茨海默病患者的颅骨板厚度与海马体积的关系","authors":"Ersin Kasım Ulusoy, Döndü Melek Ulusoy, Mehmet Fatih Göl, Ayşe Çiçek, Turgut Tursem Tokmak","doi":"10.1055/s-0044-1791658","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong> Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.</p><p><strong>Objective: </strong> To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).</p><p><strong>Methods: </strong> The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.</p><p><strong>Results: </strong> The lowest total hippocampal volume (<i>p</i> < 0.05) was in the AD group, which was 6.14 ± 0.66 mm<sup>3</sup>, while in the control group, it was 7.7 ± 9.65 mm<sup>3</sup>, and 6.69 ± 0.46 mm<sup>3</sup> in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong> The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"82 11","pages":"1-7"},"PeriodicalIF":1.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531867/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients.\",\"authors\":\"Ersin Kasım Ulusoy, Döndü Melek Ulusoy, Mehmet Fatih Göl, Ayşe Çiçek, Turgut Tursem Tokmak\",\"doi\":\"10.1055/s-0044-1791658\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong> Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.</p><p><strong>Objective: </strong> To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).</p><p><strong>Methods: </strong> The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.</p><p><strong>Results: </strong> The lowest total hippocampal volume (<i>p</i> < 0.05) was in the AD group, which was 6.14 ± 0.66 mm<sup>3</sup>, while in the control group, it was 7.7 ± 9.65 mm<sup>3</sup>, and 6.69 ± 0.46 mm<sup>3</sup> in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong> The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.</p>\",\"PeriodicalId\":8694,\"journal\":{\"name\":\"Arquivos de neuro-psiquiatria\",\"volume\":\"82 11\",\"pages\":\"1-7\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531867/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arquivos de neuro-psiquiatria\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0044-1791658\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos de neuro-psiquiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0044-1791658","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/3 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients.
Background: Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.
Objective: To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).
Methods: The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.
Results: The lowest total hippocampal volume (p < 0.05) was in the AD group, which was 6.14 ± 0.66 mm3, while in the control group, it was 7.7 ± 9.65 mm3, and 6.69 ± 0.46 mm3 in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; p < 0.05).
Conclusion: The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.
期刊介绍：
Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology.
The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.
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