通过个性化透析液浓度避免心律失常:透析患者的精准医疗案例。

IF 14.8 1区 医学 Q1 UROLOGY & NEPHROLOGY
T Alp Ikizler, Tilman B Drueke, Jürgen Floege, Germaine Wong
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引用次数: 0

摘要

心律失常在接受维持性血液透析(HD)的患者中很常见。在本期杂志上,Charytan 等人的研究表明,对于高钾血症(5.1 - 6.5 mEq/l)的血液透析患者,在无透析的日子里,透析液浓度为 3 mEq/l,同时使用环硅酸锆钠(SZC),与透析液浓度为 2 mEq/l(持续 8 周)相比,心房颤动发生率较低。尽管这项试验研究存在明显的局限性,如样本量较小、治疗时间较短以及缺乏对患者重要结果(如猝死)的长期影响方面的信息,但这项精心策划的试验研究为更大规模的前瞻性试验提供了动力,以检验这种个性化方法是否能降低主要心血管事件和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Avoiding arrythmias by personalizing the dialysate concentration: a case for precision medicine in patients on dialysis.

Cardiac arrythmias are common in patients undergoing maintenance hemodialysis. In this issue, Charytan et al. showed that in patients with hyperkalemia (serum potassium concentration 5.1-6.5 mEq/l) on hemodialysis, a dialysate concentration of 3 mEq/l combined with sodium zirconium cyclosilicate on dialysis-free days is associated with a low frequency of atrial fibrillation compared with a dialysate concentration of 2 mEq/l over 8 weeks. Despite the obvious limitations such as small sample size, short treatment period, and absence of information on longer-term impact regarding patient important outcomes such as sudden death, this well-conceived pilot study provided impetus for larger prospective trials to test whether this personalized approach reduces major cardiovascular events and mortality.

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来源期刊
Kidney international
Kidney international 医学-泌尿学与肾脏学
CiteScore
23.30
自引率
3.10%
发文量
490
审稿时长
3-6 weeks
期刊介绍: Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.
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