母体被动吸烟对小鼠新生儿心肌病的影响

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-11-04 DOI:10.1002/bdr2.2411

Naseer Kawish, Muddasir Hassan Abbasi, Muhammad Babar Khawar, Tasleem Akhtar, Amin Arif, Ayesha Majid, Nadeem Sheikh

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引用次数: 0

摘要

背景：烟草烟雾对全球都有影响，尤其是对孕妇及其新生儿。越来越多的研究表明，被动吸烟是导致先天性心血管疾病（CVDs）的重要因素：研究目的：本研究旨在模拟被动吸烟（PTS）对整个妊娠期接触被动吸烟的新生儿的影响：方法：将雌性小鼠（DPC = 0）置于专门的烟雾室中，从受孕到出生，每天吸24支烟，每支烟间隔10分钟。采用组织病理学分析评估 PTS 诱导的新生儿心脏损伤：结果：结果显示细胞结构发生了明显改变，即间隙增宽、出血、细胞核萎缩、炎性细胞浸润、胶原沉积和纤维化：结论：母亲在怀孕期间接触 PTS 可能会导致新生儿心肌病。

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The Impact of Maternal Passive Tobacco Smoke on Neonatal Myocardiopathy in Mice

Background

Tobacco smoke has a global impact, particularly on pregnant women and their newborns. An emerging body of research suggests that passive tobacco smoking is a significant contributor to congenital cardiovascular disorders (CVDs).

Aim of the Study

This study aimed to mimic the effects of passive tobacco smoke (PTS) on neonates exposed throughout the gestational period.

Methods

Female mice (DPC = 0) were exposed to PTS; 24 cigarettes/day with an interval of 10 min between each cigarette in a specialized smoke chamber from conception to birth. Histopathological analysis was employed to evaluate PTS-induced cardiac damage in neonates.

Results

The results revealed significant alterations in cell structure, namely, widened interstitial spaces, hemorrhage, pyknotic nuclei, inflammatory cell infiltration, collagen deposition, and fibrosis.

Conclusion

Maternal exposure to PTS during pregnancy may lead to neonatal myocardiopathy.

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.