心血管疾病中的血脂保护。

IF 12 1区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacology & Therapeutics Pub Date : 2024-11-02 DOI:10.1016/j.pharmthera.2024.108747

Marcel Benkhoff , Amin Polzin

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引用次数: 0

摘要

心脏保护是科学界的一个成熟术语。它描述了各种介质对心血管系统的保护作用。这些保护作用也可由某些脂质提供。由于脂质是一类非常特殊且可明确定义的物质，我们将脂质保护一词定义为脂质介导的心血管保护。在这篇综述中，我们强调高密度脂蛋白（HDL）、鞘氨醇-1-磷酸（S1P）和欧米茄-3 多不饱和脂肪酸（n-3 PUFA）是最重要的脂质保护介质，并展示了它们对冠状动脉疾病（CAD）、急性心肌梗塞（AMI）和心力衰竭（HF）的有益影响。

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Lipoprotection in cardiovascular diseases

Cardioprotection is a well-established term in the scientific world. It describes the protection of various mediators on the cardiovascular system. These protective effects can also be provided by certain lipids. Since lipids are a very specific and clearly definable class of substances, we define the term lipoprotection as lipid-mediated cardioprotection. In this review, we highlight high-density lipoprotein (HDL), sphingosine-1-phosphate (S1P) and omega-3 polyunsaturated fatty acids (n-3 PUFA) as the most important lipoprotective mediators and show their beneficial impact on coronary artery disease (CAD), acute myocardial infarction (AMI) and heart failure (HF).

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来源期刊

Pharmacology & Therapeutics 医学-药学

CiteScore

23.00

自引率

0.70%

发文量

222

审稿时长

90 days

期刊介绍： Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.