以 AgSCF3 为媒介的苯并咪唑衍生物的银介导自由基级联三氟甲基硫代化/环化反应。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-04 DOI:10.1039/d4ob01582g

Pan Liu, Yang Geng, Dapeng Zou, Yangjie Wu, Yusheng Wu

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引用次数: 0

摘要

研究了银介导的未活化烯烃的级联三氟甲基硫代/环化反应。该策略采用 AgSCF3 作为三氟甲基硫代试剂，以合理的产率获得了多种有用的三氟甲基硫代三环咪唑衍生物。初步的机理研究表明，本反应是通过自由基过程进行的。该方法具有原子经济性、广泛的官能团兼容性、操作简便性和产品多样性等特点。

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Silver-mediated radical cascade trifluoromethylthiolation/cyclization of benzimidazole derivatives with AgSCF₃.

A silver-mediated cascade trifluoromethylthiolation/cyclization of unactivated alkenes has been investigated. This strategy employs AgSCF₃ as the trifluoromethylthiolating reagent to obtain a variety of useful trifluoromethylthiolated tricyclic imidazol derivatives in reasonable yields. Preliminary mechanistic studies indicate that the present reaction takes place via a radical process. This method is distinguished by its atom economy, wide functional group compatibility, operational simplicity and product diversity.

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