一种先进的水凝胶敷料系统,可用于糖尿病伤口愈合的渐进式输送和层间反应。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Ying Liu , Tianqi Liu , Zhenye Zhu , Lin Xie , De Bai , Tonglin Liu , Wenting Gu , Wei Li , Yang Shu , Jiaheng Zhang
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引用次数: 0

摘要

由于炎症反应延迟,糖尿病患者的伤口愈合面临巨大挑战,这阻碍了随后的愈合阶段。为此,我们开发了一种渐进式逐层响应水凝胶,专门用于满足糖尿病伤口在不同愈合阶段的动态需求。这种水凝胶由 4-arm-聚(乙二醇)琥珀酰亚胺基戊二酸酯(4arm-PEG-SG)和 3-氨基苯硼酸之间的硼酸酯键形成的葡萄糖响应层开始。这种结构确保了对理化特性的精确控制,有利于在愈合过程中准确释放药物。此外,我们还加入了由双氯芬酸和左旋肉碱组成的活性药物成分离子液体(API)。这一组合有效解决了消炎药常见的溶解性和稳定性问题。为了进一步完善药物释放,我们整合了对基质金属蛋白酶-9(MMP-9)敏感的明胶微胶囊,以确保药物的可控释放,并防止其他系统中常见的药物突然分布不均的情况。我们的水凝胶的流变特性与人体皮肤非常相似,为糖尿病伤口愈合提供了一种更和谐的方法。总之,这种逐层渐进式响应伤口管理系统是一种安全、高效、智能的方法,在糖尿病伤口的临床治疗中具有巨大的潜力。意义说明:糖尿病伤口的两大问题是炎症的长期浸润和修复过程的延迟。本实验设计了一种葡萄糖响应分层给药系统,智能调节凝胶特性以满足伤口愈合过程中炎症和修复阶段的需要,加速炎症和修复阶段的转化,加快修复阶段的进程。此外,为了实现消炎层水凝胶中药物的精确释放,避免消炎小分子药物因溶解性差而突然释放,我们以双氯芬酸和左旋肉碱为原料,构建了活性药物成分离子液体(API-ILs)。将其包裹在 MMP-9 酶活性明胶微胶囊中,构建了双反应消炎层凝胶,实现了药物的精确释放。这些发现凸显了我们的系统在治疗糖尿病伤口方面的潜力,为伤口治疗带来了重大进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An advanced hydrogel dressing system with progressive delivery and layer-to-layer response for diabetic wound healing

An advanced hydrogel dressing system with progressive delivery and layer-to-layer response for diabetic wound healing
Wound healing in diabetic patients presents a significant challenge due to delayed inflammatory responses, which obstruct subsequent healing stages. In response, we have developed a progressive, layer-by-layer responsive hydrogel, specifically designed to meet the dynamic requirements of diabetic wounds throughout different healing phases. This hydrogel initiates with a glucose-responsive layer formed by boronate ester bonds between 4-arm-poly (ethylene glycol) succinimidyl glutarate (4arm-PEG-SG) and 3-aminophenylboronic acid. This configuration ensures precise control over the physicochemical properties, facilitating accurate drug release during the healing process. Furthermore, we have incorporated an active pharmaceutical ingredient ionic liquid (API) composed of diclofenac and L-carnitine. This combination effectively tackles the solubility and stability issues commonly associated with anti-inflammatory drugs. To further refine drug release, we integrated matrix metalloproteinase-9 (MMP-9)-sensitive gelatin microcapsules, ensuring a controlled release and preventing the abrupt, uneven drug distribution often seen in other systems. Our hydrogel's rheological properties closely resemble human skin, offering a more harmonious approach to diabetic wound healing. Overall, this progressive layer-by-layer responsive wound management system, which is a safe, efficient, and intelligent approach, holds significant potential for the clinical treatment of diabetic wounds.

Statement of significance

The two main problems of diabetic wounds are the long-term infiltration of inflammation and the delayed repair process. In this experiment, a glucose-responsive hierarchical drug delivery system was designed to intelligently adjust gel properties to meet the needs of inflammation and repair stage of wound healing, accelerate the transformation of inflammation and repair stage, and accelerate the process of repair stage. In addition, in order to achieve accurate drug release in anti-inflammatory layer hydrogels and avoid sudden drug release due to poor solubility of anti-inflammatory small molecule drugs, we constructed a ionic liquid of active pharmaceutical ingredients (API-ILs) using diclofenac and L-carnitine as raw materials. It was wrapped in MMP-9 enzyme active gelatin microcapsule to construct a double-reaction anti-inflammatory layer gel to achieve accurate drug release. These findings highlight the potential of our system in treating diabetic wounds, providing a significant advance in wound treatment.
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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