{"title":"一种来自海洋源真菌菌株赤曲霉 BTBU20211037 的丁内酯衍生物。","authors":"Xinwan Zhang, Renming Jia, Jinpeng Yang, Zhijun Song, Xiuli Xu, Fuhang Song","doi":"10.1080/14786419.2024.2422515","DOIUrl":null,"url":null,"abstract":"<p><p>The secondary metabolites of marine-derived fungal strain, <i>Aspergillus terreus</i> BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (<b>1</b>), and twelve known compounds, butyrolactone I (<b>2</b>), butyrolactone VI (<b>3</b>), aspernolide B (<b>4</b>), aspernolide A (<b>5</b>), 7'-hydroxybutyrolactone III (<b>6</b>), methyl asterrate (<b>7</b>), methyl dichloroasterrate (<b>8</b>), sulochrin (<b>9</b>), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (<b>10</b>), serantrypinone (<b>11</b>), alantrypinone (<b>12</b>), and territrem A (<b>13</b>). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds <b>1</b>, <b>10</b>, and <b>13</b> showed inhibitory effects against <i>Staphylococcus aureus</i> ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A butyrolactone derivative from marine-derived fungal strain <i>Aspergillus terreus</i> BTBU20211037.\",\"authors\":\"Xinwan Zhang, Renming Jia, Jinpeng Yang, Zhijun Song, Xiuli Xu, Fuhang Song\",\"doi\":\"10.1080/14786419.2024.2422515\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The secondary metabolites of marine-derived fungal strain, <i>Aspergillus terreus</i> BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (<b>1</b>), and twelve known compounds, butyrolactone I (<b>2</b>), butyrolactone VI (<b>3</b>), aspernolide B (<b>4</b>), aspernolide A (<b>5</b>), 7'-hydroxybutyrolactone III (<b>6</b>), methyl asterrate (<b>7</b>), methyl dichloroasterrate (<b>8</b>), sulochrin (<b>9</b>), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (<b>10</b>), serantrypinone (<b>11</b>), alantrypinone (<b>12</b>), and territrem A (<b>13</b>). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds <b>1</b>, <b>10</b>, and <b>13</b> showed inhibitory effects against <i>Staphylococcus aureus</i> ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2422515\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2422515","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
摘要
研究了从秦皇岛沿海分离的海洋源真菌菌株赤曲霉 BTBU20211037 的次级代谢产物。分离并鉴定了 13 个化合物，包括 1 个新化合物丁内酯 J (1)，12 个已知化合物丁内酯 I (2)、丁内酯 VI (3)、天冬内酯 B (4)、天冬内酯 A (5)、7'-羟基丁内酯 III (6)、紫菀酸甲酯 (7)、二氯紫菀酸甲酯 (8)、苏洛春内酯 (9)、6-乙酰基-4-甲氧基-5,7,8-三羟基萘-2-羧酸甲酯 (10)、丝兰内酯 (11)、丝兰内酯 (12) 和领土内酯 A (13)。这些化合物的结构通过 HRESIMS、NMR 和 ECD 分析得以阐明。化合物 1、10 和 13 对金黄色葡萄球菌 ATCC 25923 具有抑制作用，最小抑制浓度分别为 12.5、25 和 100 μg/mL。
A butyrolactone derivative from marine-derived fungal strain Aspergillus terreus BTBU20211037.
The secondary metabolites of marine-derived fungal strain, Aspergillus terreus BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (1), and twelve known compounds, butyrolactone I (2), butyrolactone VI (3), aspernolide B (4), aspernolide A (5), 7'-hydroxybutyrolactone III (6), methyl asterrate (7), methyl dichloroasterrate (8), sulochrin (9), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (10), serantrypinone (11), alantrypinone (12), and territrem A (13). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds 1, 10, and 13 showed inhibitory effects against Staphylococcus aureus ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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