糖尿病患者尿液中挥发性有机化合物与慢性肾病的关系:来自 NHANES 的实际证据。

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yu-Li Lin, Yi-Chien Yang
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引用次数: 0

摘要

背景:慢性肾病(CKD)是糖尿病(DM)患者的常见病。挥发性有机化合物(VOC)是一种广泛存在的污染物,可能会影响糖尿病的发展:本研究旨在探讨 DM 患者尿液中挥发性有机化合物代谢物与 CKD 之间的关系:本研究纳入了 2011 年至 2018 年成人国家健康与营养调查(NHANES)中的 DM 患者。CKD定义为估计肾小球滤过率(eGFR)2或尿白蛋白与肌酐比值(UACR)≥30 mg/g。采用多变量回归模型分析尿液中挥发性有机化合物代谢物与慢性肾脏病之间的关系:结果:共纳入了 1295 名患有糖尿病的参与者,他们的平均年龄为 59 岁。在对人口统计学和临床特征进行调整后,N-乙酰-S-(2-氨基甲酰乙基)-L-半胱氨酸(AAMA)水平升高(三分层 2:调整后比值比 (aOR) = 1.81,95% 置信区间 (CI):1.15-2.85,p = 0.012)、N-乙酰-S-(N-甲基氨基甲酰基)-L-半胱氨酸(AMCC)水平升高(三分层 2:aOR = 1.84,95% CI:1.10-3.08,p = 0.021)、DHBMA(三分层 3:aOR = 1.93,95% CI:1.12-3.35,p = 0.020)和苯乙酸(PGA)(三分层 3:aOR = 1.71,95% CI:1.11-2.63,p = 0.017)与患 CKD 的可能性增加显著相关:结论:特定的尿挥发性有机化合物代谢物水平与糖尿病患者罹患慢性肾脏病的风险增加呈正相关。这些研究结果表明,监测尿液中的挥发性有机化合物代谢物对预防和管理这类人群的慢性肾脏病非常重要。未来的纵向研究应侧重于确定因果关系并阐明这些关联的内在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of urinary volatile organic compounds and chronic kidney disease in patients with diabetes: real-world evidence from the NHANES.

Background: Chronic kidney disease (CKD) is common in patients with diabetes mellitus (DM). Volatile organic compounds (VOCs) are widespread pollutants that may impact DM development.

Objective: This study aims to explore the association between urinary VOC metabolites and CKD in patients with DM.

Methods: Adult National Health and Nutrition Examination Survey (NHANES) 2011 to 2018 participants with DM were included in this study. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or urine albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Multivariable regression models were used to analyze the associations between urinary VOC metabolites and CKD.

Results: A total of 1,295 participants with DM and a mean age of 59 years were included. After adjustment for demographic and clinical characteristics, elevated levels of N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) (tertile 2: adjusted odds ratio (aOR)  =   1.81, 95% confidence interval (CI): 1.15-2.85, p  =  0.012), N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC) (tertile 2: aOR   =  1.84, 95% CI: 1.10-3.08, p  =  0.021), DHBMA (tertile 3: aOR  =  1.93, 95% CI: 1.12-3.35, p  =   0.020), and phenylglyoxylic acid (PGA) (tertile 3: aOR   =  1.71, 95% CI: 1.11-2.63, p  =  0.017) were significantly associated with increased likelihood of CKD.

Conclusion: Specific urinary VOC metabolite levels are positively associated with an increased risk of CKD in patients with DM. These findings suggest that monitoring urinary VOC metabolites could be important for the prevention and management of CKD in this population. Future longitudinal studies should focus on establishing causality and elucidating the underlying mechanisms of these associations.

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来源期刊
Metabolomics
Metabolomics 医学-内分泌学与代谢
CiteScore
6.60
自引率
2.80%
发文量
84
审稿时长
2 months
期刊介绍: Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.
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