PermaNet® Dual 与 Interceptor® G2 和 PermaNet 3.0 在肯尼亚西部西亚县实验棚中的功效比较。

IF 2.4 3区 医学 Q3 INFECTIOUS DISEASES
Nashon Ogutu, Silas Agumba, Vincent Moshi, Patrick Onyango, Collins Ouma, Edith Ramaita, Lenson Kariuki, John E Gimnig, Bernard Abong'o, Eric Ochomo
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引用次数: 0

摘要

背景:在非洲,拟除虫菊酯-氯虫苯甲酰胺蚊帐对流行病学的影响明显优于纯拟除虫菊酯和拟除虫菊酯加胡椒基丁醚(PBO)蚊帐。与 Interceptor® G2 相比,PermaNet® Dual 是一种新型氯虫苯甲酰胺加溴氰菊酯蚊帐:这项研究是一项实验性小屋试验,采用 7×7 拉丁方形设计。每天在实验棚中部署七种处理方法和七个卧铺,分别每周和每天轮换一次。每天早上 06:30 至 08:30 之间收集蚊子,评估其吸血情况,然后监测收集后 1 小时的即时击倒率和 72 小时后的延迟死亡率。根据世界卫生组织(WHO)协议进行了非劣效性判定:PermaNet3.0在72小时内的死亡率为30.2%,Interceptor® G2为44.4%,PermaNet® Dual为49.2%。PermaNet® Dual的采血量最高,为15%;PermaNet® 3.0的采血量最低,为10%。PermaNet® Dual和Interceptor® G2在死亡率(OR = 1.10,95% CI 1.00-1.20)或输血量(OR = 1.18,95% CI 1.04-1.33)方面没有显著差异,置信区间下限在非劣效性范围内,但在输血量方面,非劣效性相对较高,达到95%置信区间上限。PermaNet® Dual与Interceptor® G2相比无劣效性,在导致死亡方面优于PermaNet® 3.0蚊帐,但在抑制病媒吸血方面劣于PermaNet ®3.0:PermaNet® Dual符合世界卫生组织关于Interceptor® G2的非劣效标准,可考虑用于公共卫生领域,以对付抗拟除虫菊酯的疟蚊病媒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of PermaNet® Dual compared to Interceptor® G2 and PermaNet 3.0 in experimental huts in Siaya County, western Kenya.

Background: Pyrethroid-chlorfenapyr nets have shown significant epidemiological impact over pyrethroid-only and pyrethroid plus piperonyl-butoxide (PBO) in Africa. A non-inferiority evaluation of PermaNet® Dual, a new chlorfenapyr plus deltamethrin net, compared to Interceptor® G2, was conducted in experimental huts in Siaya, Kenya against free-flying pyrethroid-resistant Anopheles funestus.

Methods: This study was an experimental hut trial, following a 7 by 7 Latin Square design. Seven treatments and seven sleepers were deployed in the experimental huts daily and rotated weekly and daily, respectively. Mosquitoes were collected every morning between 06:30 h and 08:30 h and were assessed for blood feeding and then monitored for immediate knockdown 1-h post collection and delayed mortality after 72 h. Differences in proportional outcomes were analysed using the blocked logistic regression model, while differences in numerical outcomes were analysed using the negative binomial regression model. Non-inferiority determination was performed based on World Health Organization (WHO) protocol.

Results: Mortality at 72 h was 30.2% for PermaNet 3.0, 44.4% for the Interceptor® G2 and 49.2% for the PermaNet® Dual. Blood feeding was highest with PermaNet® Dual at 15%, and least with PermaNet® 3.0 at 10%. PermaNet® Dual and Interceptor® G2 had no significant differences in mortality (OR = 1.10, 95% CI 1.00-1.20) or blood feeding (OR = 1.18, 95% CI 1.04-1.33) and the lower confidence bounds were within the non-inferiority margins but for blood feeding, non-inferiority was relatively high to the upper 95% confidence bound. PermaNet® Dual was non-inferior to the Interceptor® G2 and superior to the PermaNet® 3.0 nets in causing mortality but inferior to PermaNet ®3.0 in blood feeding inhibition of the vectors.

Conclusion: PermaNet® Dual met the WHO criteria for non-inferiority to Interceptor® G2 and may be considered for deployment for public health use against pyrethroid-resistant Anopheles vectors of malaria.

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来源期刊
Malaria Journal
Malaria Journal 医学-寄生虫学
CiteScore
5.10
自引率
23.30%
发文量
334
审稿时长
2-4 weeks
期刊介绍: Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field.
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