母体肠道微生物群影响宫内环境压力因素对人类认知发展和行为的调节。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2024-10-24 DOI:10.1016/j.jpsychires.2024.10.028

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引用次数: 0

摘要

这篇综述探讨了长期以来关于自然界和宫内环境挑战对人类发育和行为的影响的争论，并特别关注母体产前肠道微生物的影响。最近的研究揭示了肠道微生物群在人类神经发育中的关键作用，有证据表明母体微生物群会影响胎儿的基因和微环境组成，以及免疫生理学和神经化学反应。此外，胎儿宫内的神经表观遗传调控可能会受到母体微生物群的影响，从而对后代的行为和认知产生持久的影响。通过研究母体产前肠道微生物与人类发育之间的复杂关系，本综述强调了生命早期环境因素对塑造神经发育和认知的重要性。

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Maternal gut-microbiota impacts the influence of intrauterine environmental stressors on the modulation of human cognitive development and behavior

This review examines the longstanding debate of nature and intrauterine environmental challenges that shapes human development and behavior, with a special focus on the influence of maternal prenatal gut microbes. Recent research has revealed the critical role of the gut microbiome in human neurodevelopment, and evidence suggest that maternal microbiota can impact fetal gene and microenvironment composition, as well as immunophysiology and neurochemical responses. Furthermore, intrauterine neuroepigenetic regulation may be influenced by maternal microbiota, capable of having long-lasting effects on offspring behavior and cognition. By examining the complex relationship between maternal prenatal gut microbes and human development, this review highlights the importance of early-life environmental factors in shaping neurodevelopment and cognition.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;