非霍奇金淋巴瘤患者输注抗 CD19 CAR-T 细胞后的糖酵解活动。

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2024-11-01 DOI:10.1111/eci.14342

Nicolas Vallet, Laurianne Drieu Larochelle, Maria-Joao Santiago-Ribeiro, Alban Villate, Martin Eloit, Arnaud Cirée, Laura Zaragoza, Virginie André, Marie Prat-Lepesant, Olivier Hérault, Flavie Arbion, Hélène Blasco, Emmanuel Gyan

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引用次数: 0

摘要

人类嵌合抗原受体-T细胞（CAR-T）激活后的能量代谢仍未得到研究。作为糖酵解活性的替代物，我们研究了CAR-T输注后头几周外周血（PB）乳酸的动态变化。在17名接受CD28携带抗CD19 CAR-T治疗的复发/难治性非霍奇金淋巴瘤患者中，CAR-T输注后外周血乳酸水平升高。乳酸水平升高与 CAR-T 持续时间延长和 CD8+/CD4+ 比率升高相关。外周血乳酸动力学可反映免疫细胞的活化情况，有助于床旁监测。

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Glycolytic activity following anti-CD19 CAR-T cell infusion in non-Hodgkin lymphoma.

Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lactate in the first weeks post-CAR-T infusion. In 17 patients treated with CD28 harbording anti-CD19 CAR-T for relapsed/refractory non-Hodgkin lymphomas, PB lactate levels increased following CAR-T infusion. Elevated lactate levels correlated with longer CAR-T persistence and higher CD8+/CD4+ ratio. Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring.

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.