2 型糖尿病患者代谢功能障碍相关性脂肪肝:心力衰竭的风险。

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Rosa Oh, Gyuri Kim, Kyu-Na Lee, So Hyun Cho, Ji Yoon Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
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引用次数: 0

摘要

背景和目的:代谢功能障碍相关性脂肪性肝病(MASLD)与2型糖尿病(T2DM)患者心血管预后之间的关系尚不明确。本研究旨在探讨SLD谱对T2DM患者心力衰竭和心血管(CV)死亡风险的影响:在一项全国性队列研究中,从 2009 年到 2012 年,对 2,745,689 名患有 T2DM 的成年人进行了随访,直至 2018 年。参与者被分为无脂肪肝组(无 SLD)和 SLD 组。SLD组根据代谢风险因素、饮酒量和病毒性肝炎进行分层。采用Cox比例危险模型估算心力衰竭(HF)和心血管疾病死亡风险的危险比(HRs)和95%置信区间(CIs):MASLD、代谢性酒精相关肝病(MetALD)、酒精相关肝病伴代谢功能障碍(ALD伴MD)和MASLD伴病毒性肝炎(VH)的发病率分别为49.6%、7.2%、2.3%和2.0%。与无 SLD 组相比,MASLD(调整 HR [aHR],1.11)、MetALD(aHR,1.14)、ALD 伴 MD(aHR,1.32)和 MASLD 伴 VH(aHR,1.12)患者罹患 HF 的风险更高。与无 SLD 组相比,有 SLD 组的心血管疾病死亡风险也更高。无论SLD状况如何,新发HF和CV死亡风险与饮酒量呈 "J "形关系:结论:SLD是T2DM患者新发高血压和心血管疾病死亡的独立风险因素,无论SLD状况如何,饮酒与高血压和心血管疾病死亡风险呈 "J "形关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes: risk of heart failure.

Background and aims: The association between metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM) is unclear. This study aimed to investigate the impact of spectrum of SLD on the risk of heart failure and cardiovascular (CV) mortality in patients with T2DM.

Methods: In a nationwide cohort study, 2,745,689 adults with T2DM were followed from 2009 to 2012 until 2018. Participants were categorized into no steatotic liver disease (no SLD) and SLD groups. The SLD group was stratified based on metabolic risk factors, alcohol consumption and viral hepatitis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for heart failure (HF) and CV mortality risk.

Results: The prevalence of MASLD, metabolic alcohol-associated liver disease (MetALD), alcohol-associated liver disease with metabolic dysfunction (ALD with MD) and MASLD with viral hepatitis (VH) was 49.6%, 7.2%, 2.3%, and 2.0%. Individuals with MASLD (adjusted HR [aHR], 1.11), MetALD (aHR, 1.14), ALD with MD (aHR, 1.32) and MASLD with VH (aHR, 1.12) had a higher risk of developing HF compared with the no SLD group. The risk of CV mortality was also increased in those with SLD groups compared to those with no SLD. The risk of new-onset HF and CV mortality showed a J-shaped association with alcohol consumption regardless of SLD status.

Conclusion: SLD is independent risk factor of new-onset HF and CV mortality in persons with T2DM, and alcohol consumption has a J-shaped association with risk of HF and CV mortality, regardless of SLD status.

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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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