结缔组织疾病患者的相位角与肌肉疏松症之间的关系。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-10-30 DOI:10.1016/j.clnesp.2024.10.159

Toshiyuki Moriyama , Mizuki Tokunaga , Ryoko Hori , Akiko Hachisuka , Hideaki Itoh , Mitsuhiro Ochi , Yasuyuki Matsushima , Satoru Saeki

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引用次数: 0

摘要

背景与目的：结缔组织疾病（CTD）患者肌肉疏松症的早期检测和治疗至关重要。然而，CTD 患者的相位角与肌肉疏松症之间的关系尚不清楚。本研究调查了结缔组织病患者的相位角与肌少症之间的关系，并确定了早期发现肌少症的最佳相位角临界值：这项回顾性横断面研究的对象是 279 名住院接受康复治疗的 CTD 患者（中位年龄 73.3 岁；男性 80 人，女性 199 人）。研究采用生物阻抗分析法测量相位角，并根据亚洲肌少症工作组的标准评估肌少症：结果：134 名患者（36 名男性和 98 名女性）被发现患有肌肉疏松症。肌少症患者的相位角明显小于无肌少症患者。多变量分析显示，在调整了各种性别的混杂因素后，相位角与肌肉疏松症明显相关。识别肌肉疏松症的最佳相位角临界值男性为 4.6°，女性为 4.3°，曲线下面积值分别为 0.795 和 0.754：相位角是鉴别 CTD 患者肌少症的重要指标。结论：相位角是鉴别 CTD 患者肌肉疏松症的重要指标，将男性相位角截断值定为 4.6°，女性相位角截断值定为 4.3°，有助于早期发现和治疗肌肉疏松症。

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Association between phase angle and sarcopenia in patients with connective tissue diseases

Background and aims

Early detection and management of sarcopenia in patients with connective tissue diseases (CTDs) are essential. However, the relationship between the phase angle and sarcopenia in patients with CTDs is unknown. This study investigated the association between the phase angle and sarcopenia in patients with (CTDs) and determined the optimal phase angle cutoff values for the early detection of sarcopenia.

Methods

A retrospective cross-sectional study was conducted in 279 hospitalized patients with CTDs undergoing rehabilitation (median age 73.3 years; 80 men and 199 women). Bioimpedance analysis was used to measure the phase angle, and sarcopenia was assessed according to the Asian Working Group for Sarcopenia criteria.

Results

Sarcopenia was identified in 134 patients (36 men and 98 women). Patients with sarcopenia had a significantly smaller phase angle than those without sarcopenia. Multivariate analysis revealed that phase angle was significantly associated with sarcopenia after adjusting for confounding factors in each sex. The optimal phase angle cutoff value for identifying sarcopenia was 4.6° for men and 4.3° for women, with area under the curve values of 0.795 and 0.754, respectively.

Conclusion

Phase angle is a valuable marker for identifying sarcopenia in patients with CTDs. The established phase angle cutoff values of 4.6° in men and 4.3° in women can facilitate the early detection and management of sarcopenia.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.