Elisa Mantovani, Alice Martini, Alessandro Dinoto, Chiara Zucchella, Sergio Ferrari, Sara Mariotto, Michele Tinazzi, Stefano Tamburin
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引用次数: 0
摘要
认知障碍（CI）常见于α-突触核蛋白病，即帕金森病、路易体痴呆和多系统萎缩。我们总结了有关α-突触核蛋白病中CI的神经影像学、神经生理学、生物流体和基因诊断/预后生物标志物的系统综述/元分析数据。皮质胆碱能和谷氨酸能活性降低，皮质 GABA 能活性增加，P300 潜伏期延迟，血浆同型半胱氨酸和胱抑素 C 增加，维生素 B12 和叶酸减少，CSF/血清白蛋白商增加，血清神经丝轻链增加。预后生物标志物包括脑区域萎缩、皮质节律减慢、CSF淀粉样蛋白生物标志物、Val66Met多态性、载脂蛋白-E ε2和ε4等位基因。一些AD/淀粉样蛋白/tau生物标志物可诊断/预测α-突触核蛋白病的CI，但缺乏单一、有效的诊断/预后生物标志物。未来的研究应包括大型联盟、生物库、多组学方法、人工智能和机器学习，以更好地反映α-突触核蛋白病中CI的复杂性。
Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses.
Cognitive impairment (CI) is common in α-synucleinopathies, i.e., Parkinson's disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. Diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers, cortical rhythm slowing, reduced cortical cholinergic and glutamatergic and increased cortical GABAergic activity, delayed P300 latency, increased plasma homocysteine and cystatin C and decreased vitamin B12 and folate, increased CSF/serum albumin quotient, and serum neurofilament light chain. Prognostic biomarkers include brain regional atrophy, cortical rhythm slowing, CSF amyloid biomarkers, Val66Met polymorphism, and apolipoprotein-E ε2 and ε4 alleles. Some AD/amyloid/tau biomarkers may diagnose/predict CI in α-synucleinopathies, but single, validated diagnostic/prognostic biomarkers lack. Future studies should include large consortia, biobanks, multi-omics approach, artificial intelligence, and machine learning to better reflect the complexity of CI in α-synucleinopathies.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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