新生儿血培养物中凝固酶阴性葡萄球菌的阳性反应时间,作为帮助鉴别败血症和污染的辅助工具。

IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Silvia Carbonell-Sahuquillo, Beatriz Olea, Raquel Pérez-Suárez, Estela Giménez, Javier Colomina, David Navarro, Javier Estañ-Capell
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引用次数: 0

摘要

目的:评估在凝固酶阴性葡萄球菌(CoNS)分离物中区分败血症和污染的有用性:评估阳性时间(TTP)在区分凝固酶阴性葡萄球菌(CoNS)分离物败血症和污染方面的作用:研究设计:单中心回顾性观察。研究回顾了 168 例疑似败血症且 CoNS 血培养阳性患者的病历。患者被细分为败血症(29%)和疑似污染(71%)。对与败血症相关的不同风险因素和临床症状进行了逻辑回归分析:结果:发现最能区分败血症和污染的TTP临界值为18小时。回归分析表明,TTP ≤ 18 h、胎龄 ≤ 32 周、心动过速/心动过缓和活动不足/嗜睡是败血症的独立预测因素:结论:TTP有助于区分败血症和污染,尤其是对胎龄较小的新生儿(胎龄≤32周)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time to positivity of Coagulase Negative Staphylococcus In Neonatal Blood Cultures as an adjunct tool to help discriminate between sepsis and contamination.

Objective: To assess the usefulness of time to positivity (TTP) to distinguish between sepsis and contamination in coagulase-negative staphylococci (CoNS) isolates.

Study design: Unicentric retrospective observational. Medical records of 168 patients with suspected sepsis and positive blood culture for CoNS were reviewed. Patients were subdivided into sepsis (29%) and probable contamination (71%). Logistic regression analyses were performed to evaluate different risk factors and clinical signs and symptoms associated with sepsis.

Results: TTP cut-off value that best discriminated sepsis from contamination was found to be 18 h. Regression analysis revealed that TTP ≤ 18 h, gestational age ≤32 weeks, taquycardia/bradycardia and hypoactivity/lethargy were independent predictors of sepsis.

Conclusion: TTP is useful in distinguishing sepsis from contamination, especially in neonates with lower gestational age (<32 weeks). The clinical signs that most increase the discriminatory power of TTP are the presence of tachycardia/bradycardia or hypoactivity.

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来源期刊
Journal of Perinatology
Journal of Perinatology 医学-妇产科学
CiteScore
5.40
自引率
6.90%
发文量
284
审稿时长
3-8 weeks
期刊介绍: The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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