Wenbin Zhang, Yulin Ma, Feilong Lu, Hao Song, Yimei Hu
{"title":"胫骨高位截骨术联合富血小板血浆治疗膝骨关节炎的有效性和安全性:一项针对中国人群的系统回顾和荟萃分析。","authors":"Wenbin Zhang, Yulin Ma, Feilong Lu, Hao Song, Yimei Hu","doi":"10.1186/s12891-024-08004-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To systematically review the clinical efficacy and safety of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for treating knee osteoarthritis (KOA) and to provide evidence of the effectiveness of evidence-based medicine for treating this disease.</p><p><strong>Methods: </strong>Clinical studies on the use of HTO combined with PRP for the treatment of KOA before September 2024 were identified. The literature that met the inclusion criteria was strictly screened out, the literature information was extracted, and the data were input into RevMan5.4 for analysis.</p><p><strong>Results: </strong>Ten studies (12 controls) with 625 patients were included. Overall, the visual analog scale (VAS) score (mean difference (MD) = -0.53, 95% confidence interval (CI) (-0.76, -0.31), P < 0.00001), range of motion (ROM) (MD = 7.24, 95% CI (2.79, 11.69), P = 0.001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (MD = -6.91, 95% CI (-9.47, -4.34), P < 0.00001), cartilage recovery (cartilage thickness: MD = 0.43, 95% CI (0.35, 0.51), P < 0.00001; cartilage regeneration: relative risk (RR) = 1.81, 95% CI (1.40, 2.33), P < 0.00001; and the International Cartilage Repair Society (ICRS) grade: RR = 1.96, 95% CI (1.44, 2.66), P < 0.0001), and the Lysholm score (MD = 6.51, 95% CI (4.97, 8.04), P < 0.00001) after HTO-PRP treatment had certain advantages compared to the control group. After treatment, there was no statistically significant difference in the knee joint mechanical axis angle between the HTO-PRP group and the control group (femoral tibial angle (FTA): MD = -0.29, 95% CI (-1.07, 0.49), P = 0.47; medial proximal tibial angle (MPTA): MD = 0.19, 95% CI (-0.49, 0.88), P = 0.58; posterior tibial slope (PTS): MD = -0.12, 95% CI (-0.49, 0.25), P = 0.53; knee varus angle (KVA): MD = -0.30, 95% CI (-1.77, 1.17), P = 0.69; weight-bearing line (WBL): MD = 1.10, 95% CI (-0.89, 3.09), P = 0.28).</p><p><strong>Conclusion: </strong>The results showed that in the treatment of KOA, the HTO-PRP group had better efficacy than the control groups did and had certain safety reliability.</p>","PeriodicalId":9189,"journal":{"name":"BMC Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529028/pdf/","citationCount":"0","resultStr":"{\"title\":\"Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population.\",\"authors\":\"Wenbin Zhang, Yulin Ma, Feilong Lu, Hao Song, Yimei Hu\",\"doi\":\"10.1186/s12891-024-08004-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To systematically review the clinical efficacy and safety of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for treating knee osteoarthritis (KOA) and to provide evidence of the effectiveness of evidence-based medicine for treating this disease.</p><p><strong>Methods: </strong>Clinical studies on the use of HTO combined with PRP for the treatment of KOA before September 2024 were identified. The literature that met the inclusion criteria was strictly screened out, the literature information was extracted, and the data were input into RevMan5.4 for analysis.</p><p><strong>Results: </strong>Ten studies (12 controls) with 625 patients were included. Overall, the visual analog scale (VAS) score (mean difference (MD) = -0.53, 95% confidence interval (CI) (-0.76, -0.31), P < 0.00001), range of motion (ROM) (MD = 7.24, 95% CI (2.79, 11.69), P = 0.001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (MD = -6.91, 95% CI (-9.47, -4.34), P < 0.00001), cartilage recovery (cartilage thickness: MD = 0.43, 95% CI (0.35, 0.51), P < 0.00001; cartilage regeneration: relative risk (RR) = 1.81, 95% CI (1.40, 2.33), P < 0.00001; and the International Cartilage Repair Society (ICRS) grade: RR = 1.96, 95% CI (1.44, 2.66), P < 0.0001), and the Lysholm score (MD = 6.51, 95% CI (4.97, 8.04), P < 0.00001) after HTO-PRP treatment had certain advantages compared to the control group. After treatment, there was no statistically significant difference in the knee joint mechanical axis angle between the HTO-PRP group and the control group (femoral tibial angle (FTA): MD = -0.29, 95% CI (-1.07, 0.49), P = 0.47; medial proximal tibial angle (MPTA): MD = 0.19, 95% CI (-0.49, 0.88), P = 0.58; posterior tibial slope (PTS): MD = -0.12, 95% CI (-0.49, 0.25), P = 0.53; knee varus angle (KVA): MD = -0.30, 95% CI (-1.77, 1.17), P = 0.69; weight-bearing line (WBL): MD = 1.10, 95% CI (-0.89, 3.09), P = 0.28).</p><p><strong>Conclusion: </strong>The results showed that in the treatment of KOA, the HTO-PRP group had better efficacy than the control groups did and had certain safety reliability.</p>\",\"PeriodicalId\":9189,\"journal\":{\"name\":\"BMC Musculoskeletal Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529028/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Musculoskeletal Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12891-024-08004-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Musculoskeletal Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12891-024-08004-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population.
Objective: To systematically review the clinical efficacy and safety of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for treating knee osteoarthritis (KOA) and to provide evidence of the effectiveness of evidence-based medicine for treating this disease.
Methods: Clinical studies on the use of HTO combined with PRP for the treatment of KOA before September 2024 were identified. The literature that met the inclusion criteria was strictly screened out, the literature information was extracted, and the data were input into RevMan5.4 for analysis.
Results: Ten studies (12 controls) with 625 patients were included. Overall, the visual analog scale (VAS) score (mean difference (MD) = -0.53, 95% confidence interval (CI) (-0.76, -0.31), P < 0.00001), range of motion (ROM) (MD = 7.24, 95% CI (2.79, 11.69), P = 0.001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (MD = -6.91, 95% CI (-9.47, -4.34), P < 0.00001), cartilage recovery (cartilage thickness: MD = 0.43, 95% CI (0.35, 0.51), P < 0.00001; cartilage regeneration: relative risk (RR) = 1.81, 95% CI (1.40, 2.33), P < 0.00001; and the International Cartilage Repair Society (ICRS) grade: RR = 1.96, 95% CI (1.44, 2.66), P < 0.0001), and the Lysholm score (MD = 6.51, 95% CI (4.97, 8.04), P < 0.00001) after HTO-PRP treatment had certain advantages compared to the control group. After treatment, there was no statistically significant difference in the knee joint mechanical axis angle between the HTO-PRP group and the control group (femoral tibial angle (FTA): MD = -0.29, 95% CI (-1.07, 0.49), P = 0.47; medial proximal tibial angle (MPTA): MD = 0.19, 95% CI (-0.49, 0.88), P = 0.58; posterior tibial slope (PTS): MD = -0.12, 95% CI (-0.49, 0.25), P = 0.53; knee varus angle (KVA): MD = -0.30, 95% CI (-1.77, 1.17), P = 0.69; weight-bearing line (WBL): MD = 1.10, 95% CI (-0.89, 3.09), P = 0.28).
Conclusion: The results showed that in the treatment of KOA, the HTO-PRP group had better efficacy than the control groups did and had certain safety reliability.
期刊介绍:
BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.