抑制铜绿假单胞菌生长和毒性的创新方法:现状与未来方向

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Sandip Patil, Xiaowen Chen, Feiqiu Wen
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引用次数: 0

摘要

铜绿假单胞菌是一种耐抗生素的机会性病原体,给治疗感染,尤其是免疫力低下者的感染带来了巨大挑战。本综述探讨了当前和未来抑制其生长和毒力的创新方法。我们深入研究了该细菌的毒力因子,讨论了抗生素、噬菌体、益生菌和小分子抑制剂等现有策略。此外,包括 RNA 干扰、CRISPR-Cas 系统和纳米技术在内的新方法也在临床前研究中显示出前景。尽管取得了进步,但挑战依然存在,因此需要针对铜绿假单胞菌发病机制的各个方面采取多方面的方法,以有效控制感染。本综述从一个全面的角度阐述了针对铜绿假单胞菌的创新策略的现状和未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions

Pseudomonas aeruginosa, an antibiotic-resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small-molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. Despite advancements, challenges persist, prompting the need for a multifaceted approach targeting various aspects of P. aeruginosa pathogenesis for effective infection management. This review provides a comprehensive perspective on the status and future directions of innovative strategies against P. aeruginosa.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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