确定更昔洛韦治疗巨细胞病毒感染免疫功能低下儿童的治疗目标：简要报告。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-10-30 DOI:10.1097/INF.0000000000004602

Maggie Gao, Heather Weerdenburg, Wenyu Yang, Xiao Zhu, Amanda Gwee

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引用次数: 0

摘要

更昔洛韦和缬更昔洛韦是治疗免疫力低下儿童巨细胞病毒的一线药物，但最佳治疗目标仍不明确。本综述确定了 6 项研究，这些研究显示巨细胞病毒病毒血症的清除率在 23 到 70 μg-h/mL 之间，中位浓度-时间曲线下面积 (AUC24) 与疗效或毒性没有明确的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Defining a Therapeutic Target for Ganciclovir Therapy in Immunocompromised Children With Cytomegalovirus Infection: A Brief Report.

Ganciclovir and valganciclovir are first-line treatments for cytomegalovirus in immunocompromised children; however, the optimal therapeutic target remains unclear. This review identified 6 studies that showed clearance of cytomegalovirus viremia occurs with a median area under the concentration-time curve (AUC24) between 23 and 70 μg·h/mL, with no clear correlation with efficacy or toxicity.

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.