神经退行性疾病:从齿鲸身上能学到什么?

IF 5.9 2区 医学 Q1 NEUROSCIENCES
Simona Sacchini
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引用次数: 0

摘要

神经退行性变涉及一系列影响神经细胞完整性、生理学和结构的神经病理学改变。许多研究都证明了不同动物的神经变性。就阿尔茨海默病(AD)而言,自发动物模型应显示两个神经组织病理学标志:β-淀粉样蛋白沉积和神经纤维缠结排列。然而,目前还没有符合这些条件的天然动物模型的报道,大多数有关注意力缺失症的研究都是通过转基因啮齿动物进行的。最近的研究还表明,齿鲸--同温、长寿、顶级掠食性海洋哺乳动物--表现出类似于注意力缺失症的神经病理学迹象。这些鲸目动物的神经病理学特征有助于更好地了解它们的濒危健康状况以及人类的神经退行性疾病。这篇系统性综述分析了迄今为止发表的有关这一趋势性主题的所有文献,并从 "一个健康"/"行星健康 "和转化医学的角度探讨了这些标志性海洋哺乳动物神经变性的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?

Neurodegeneration involves a wide range of neuropathological alterations affecting the integrity, physiology, and architecture of neural cells. Many studies have demonstrated neurodegeneration in different animals. In the case of Alzheimer's disease (AD), spontaneous animal models should display two neurohistopathological hallmarks: the deposition of β-amyloid and the arrangement of neurofibrillary tangles. However, no natural animal models that fulfill these conditions have been reported and most research into AD has been performed using transgenic rodents. Recent studies have also demonstrated that toothed whales - homeothermic, long-lived, top predatory marine mammals - show neuropathological signs of AD-like pathology. The neuropathological hallmarks in these cetaceans could help to better understand their endangered health as well as neurodegenerative diseases in humans. This systematic review analyzes all the literature published to date on this trending topic and the proposed causes for neurodegeneration in these iconic marine mammals are approached in the context of One Health/Planetary Health and translational medicine.

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来源期刊
Neuroscience bulletin
Neuroscience bulletin NEUROSCIENCES-
CiteScore
7.20
自引率
16.10%
发文量
163
审稿时长
6-12 weeks
期刊介绍: Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.
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