合成利拉鲁肽的可持续化学酶法

IF 7.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Sustainable Chemistry & Engineering Pub Date : 2024-10-31 DOI:10.1021/acssuschemeng.4c07543

Silvia Rizzo, Ana Toplak, Marco Macis, Lucia Ferrazzano, Antonio Ricci, Alessandra Tolomelli, Walter Cabri

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引用次数: 0

摘要

由于多肽在医药市场的地位日益突出，开发绿色多肽合成方法至关重要。传统方法往往涉及有害溶剂和高能耗，这促使人们转向可持续和环保的替代方法。利拉鲁肽是一种用于治疗肥胖症和 2 型糖尿病的 GLP-1 类似物，它是通过一种混合化学酶法（CEPS）合成的，在合成多肽片段时利用了绿色溶剂混合物，并利用连接酶的选择性将它们连接起来。这种方法在上游废料的质量和减少下游纯化的溶剂用量方面都有很大优势，同时还能获得高纯度的目标利拉鲁肽。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Sustainable Chemo-Enzymatic Approach to the Synthesis of Liraglutide

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A Sustainable Chemo-Enzymatic Approach to the Synthesis of Liraglutide

The development of green approaches to peptide synthesis is essential, as peptides are gaining prominence in the pharmaceutical market. Traditional methods often involve harmful solvents and high energy use, prompting a shift toward sustainable and eco-friendly alternatives. Liraglutide, a GLP-1 analogue used in the treatment of obesity and type-2 diabetes, has been synthesized through a hybrid chemo-enzymatic approach (CEPS), taking advantage of green solvent mixtures in the synthesis of peptide fragments and of selectivity of a ligase enzyme for their coupling. This method offers great advantages both in the quality of the upstream wastes and in the reduction of solvent volumes in downstream purification, together with the high purity of the target liraglutide.

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来源期刊

ACS Sustainable Chemistry & Engineering CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

13.80

自引率

4.80%

发文量

1470

审稿时长

1.7 months

期刊介绍： ACS Sustainable Chemistry & Engineering is a prestigious weekly peer-reviewed scientific journal published by the American Chemical Society. Dedicated to advancing the principles of green chemistry and green engineering, it covers a wide array of research topics including green chemistry, green engineering, biomass, alternative energy, and life cycle assessment. The journal welcomes submissions in various formats, including Letters, Articles, Features, and Perspectives (Reviews), that address the challenges of sustainability in the chemical enterprise and contribute to the advancement of sustainable practices. Join us in shaping the future of sustainable chemistry and engineering.