用于区域特异性二取代的 2A,2B-二磺化 β-环糊精的无色谱法合成

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
Christopher J. Hobbs, Vít Novotný, Michal Řezanka
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引用次数: 0

摘要

环糊精及其衍生物因其独特的疏水性空腔,在制药、化妆品和食品工业中有着广泛的应用。虽然单取代环糊精衍生物已有成熟的合成方案,但二取代衍生物却面临着产量低、纯化过程复杂等重大挑战。本研究提出了一种合成二取代环糊精衍生物的新方法,无需依赖色谱技术即可达到 33% 的产率。这种新方法简化了合成和纯化过程,使其更适用于大规模应用,并提高了环糊精衍生物在各行业中的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chromatography-free synthesis of 2A,2B-disulfonated β-cyclodextrin for regiospecific di-substitution

Chromatography-free synthesis of 2A,2B-disulfonated β-cyclodextrin for regiospecific di-substitution
Cyclodextrins and their derivatives have extensive applications across pharmaceuticals, cosmetics, and the food industry due to their unique hydrophobic cavities. While monosubstituted cyclodextrin derivatives have established synthesis protocols, di-substituted derivatives pose significant challenges, including low yields and complex purification processes. This study presents a novel methodology for synthesizing di-substituted cyclodextrin derivatives, achieving a 33 % yield without relying on chromatographic techniques. This new approach streamlines the synthesis and purification process, making it more practical for large-scale applications and enhancing the utility of cyclodextrin derivatives in various industries.
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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