石墨烯量子点作为环保型荧光探针,用于灵敏、选择性地测定药物制剂中的鲁马培酮:绿色和蓝色评估

IF 4.3 2区 化学 Q1 SPECTROSCOPY
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引用次数: 0

摘要

本研究探讨了石墨烯量子点(GQDs)作为荧光探针测定抗精神病药物鲁米培酮的潜力。研究考察了荧光探针的光谱特性和传感机制,发现了一种由 Stern-Volmer 分析法显示的静态淬灭机制。对影响淬灭过程的不同因素,如 pH 值、QDs 浓度和孵育时间等,进行了细致的调整。该方法在0.5-2.5 μg/mL范围内线性关系良好,检出限和定量限分别为0.1226 μg/mL和0.3714 μg/mL,具有较高的准确度、精密度、稳健性和选择性。此外,还使用GAPI、AGREE和BAGI工具对该方法的绿色性和蓝色性进行了评估,结果表明该方法的AGREE得分为0.78,BAGI得分为75,证实了该方法的环境友好性和分析实用性。该方法成功地用于测定药物制剂中的鲁马培酮,突出了其在常规质量控制分析中的潜力。这项研究证明了 GQDs 在灵敏、选择性地检测抗精神病药物鲁马培酮方面具有良好的分析能力,为现有分析技术提供了一种简单、快速、绿色的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Graphene quantum dots as eco-friendly fluorescent probes for sensitive and selective determination of lumateperone in pharmaceutical preparation: Greenness and blueness assessment

Graphene quantum dots as eco-friendly fluorescent probes for sensitive and selective determination of lumateperone in pharmaceutical preparation: Greenness and blueness assessment
This study investigates the potential of graphene quantum dots (GQDs) as fluorescent probes for the determination of the antipsychotic drug lumateperone. The spectral characteristics and sensing mechanism of the fluorescent probes were examined, revealing a static quenching mechanism as indicated by the Stern-Volmer analysis. Different factors affecting the quenching process, such as pH, concentration of QDs, and incubation time, were carefully tuned. The developed method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.5–2.5 μg/mL, limits of detection and quantification of 0.1226 μg/mL and 0.3714 μg/mL, respectively, and high accuracy, precision, robustness and selectivity. Furthermore, the greenness and blueness of the proposed method were assessed using GAPI, AGREE, and BAGI tools, yielding an AGREE score of 0.78 and a BAGI score of 75 confirming its environmentally benign nature as well as analytical practicality. The method was successfully applied to determine lumateperone in a pharmaceutical formulation, highlighting its potential for routine quality control analysis. This study demonstrates the promising analytical capabilities of GQDs for the sensitive and selective detection of antipsychotic drug lumateperone, offering a simple, rapid, and green alternative to existing analytical techniques.
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来源期刊
CiteScore
8.40
自引率
11.40%
发文量
1364
审稿时长
40 days
期刊介绍: Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.
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