{"title":"石墨烯量子点作为环保型荧光探针,用于灵敏、选择性地测定药物制剂中的鲁马培酮:绿色和蓝色评估","authors":"","doi":"10.1016/j.saa.2024.125342","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the potential of graphene quantum dots (GQDs) as fluorescent probes for the determination of the antipsychotic drug lumateperone. The spectral characteristics and sensing mechanism of the fluorescent probes were examined, revealing a static quenching mechanism as indicated by the Stern-Volmer analysis. Different factors affecting the quenching process, such as pH, concentration of QDs, and incubation time, were carefully tuned. The developed method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.5–2.5 μg/mL, limits of detection and quantification of 0.1226 μg/mL and 0.3714 μg/mL, respectively, and high accuracy, precision, robustness and selectivity. Furthermore, the greenness and blueness of the proposed method were assessed using GAPI, AGREE, and BAGI tools, yielding an AGREE score of 0.78 and a BAGI score of 75 confirming its environmentally benign nature as well as analytical practicality. The method was successfully applied to determine lumateperone in a pharmaceutical formulation, highlighting its potential for routine quality control analysis. This study demonstrates the promising analytical capabilities of GQDs for the sensitive and selective detection of antipsychotic drug lumateperone, offering a simple, rapid, and green alternative to existing analytical techniques.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Graphene quantum dots as eco-friendly fluorescent probes for sensitive and selective determination of lumateperone in pharmaceutical preparation: Greenness and blueness assessment\",\"authors\":\"\",\"doi\":\"10.1016/j.saa.2024.125342\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study investigates the potential of graphene quantum dots (GQDs) as fluorescent probes for the determination of the antipsychotic drug lumateperone. The spectral characteristics and sensing mechanism of the fluorescent probes were examined, revealing a static quenching mechanism as indicated by the Stern-Volmer analysis. Different factors affecting the quenching process, such as pH, concentration of QDs, and incubation time, were carefully tuned. The developed method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.5–2.5 μg/mL, limits of detection and quantification of 0.1226 μg/mL and 0.3714 μg/mL, respectively, and high accuracy, precision, robustness and selectivity. Furthermore, the greenness and blueness of the proposed method were assessed using GAPI, AGREE, and BAGI tools, yielding an AGREE score of 0.78 and a BAGI score of 75 confirming its environmentally benign nature as well as analytical practicality. The method was successfully applied to determine lumateperone in a pharmaceutical formulation, highlighting its potential for routine quality control analysis. This study demonstrates the promising analytical capabilities of GQDs for the sensitive and selective detection of antipsychotic drug lumateperone, offering a simple, rapid, and green alternative to existing analytical techniques.</div></div>\",\"PeriodicalId\":433,\"journal\":{\"name\":\"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1386142524015087\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPECTROSCOPY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1386142524015087","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
Graphene quantum dots as eco-friendly fluorescent probes for sensitive and selective determination of lumateperone in pharmaceutical preparation: Greenness and blueness assessment
This study investigates the potential of graphene quantum dots (GQDs) as fluorescent probes for the determination of the antipsychotic drug lumateperone. The spectral characteristics and sensing mechanism of the fluorescent probes were examined, revealing a static quenching mechanism as indicated by the Stern-Volmer analysis. Different factors affecting the quenching process, such as pH, concentration of QDs, and incubation time, were carefully tuned. The developed method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.5–2.5 μg/mL, limits of detection and quantification of 0.1226 μg/mL and 0.3714 μg/mL, respectively, and high accuracy, precision, robustness and selectivity. Furthermore, the greenness and blueness of the proposed method were assessed using GAPI, AGREE, and BAGI tools, yielding an AGREE score of 0.78 and a BAGI score of 75 confirming its environmentally benign nature as well as analytical practicality. The method was successfully applied to determine lumateperone in a pharmaceutical formulation, highlighting its potential for routine quality control analysis. This study demonstrates the promising analytical capabilities of GQDs for the sensitive and selective detection of antipsychotic drug lumateperone, offering a simple, rapid, and green alternative to existing analytical techniques.
期刊介绍:
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science.
The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments.
Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate.
Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to:
Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences,
Novel experimental techniques or instrumentation for molecular spectroscopy,
Novel theoretical and computational methods,
Novel applications in photochemistry and photobiology,
Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.