槲皮素对矿化牙齿组织的影响：范围综述

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2024-10-24 DOI:10.1016/j.archoralbio.2024.106119

Gabriel Pereira Nunes , Renata de Oliveira Alves , Matheus Henrique Faccioli Ragghianti , Alexandre Henrique dos Reis-Prado , Priscila Toninatto Alves de Toledo , Tamires Passadori Martins , Ana Paula Miranda Vieira , Geórgia Rondó Peres , Cristiane Duque

{"title":"槲皮素对矿化牙齿组织的影响：范围综述","authors":"Gabriel Pereira Nunes , Renata de Oliveira Alves , Matheus Henrique Faccioli Ragghianti , Alexandre Henrique dos Reis-Prado , Priscila Toninatto Alves de Toledo , Tamires Passadori Martins , Ana Paula Miranda Vieira , Geórgia Rondó Peres , Cristiane Duque","doi":"10.1016/j.archoralbio.2024.106119","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This scoping review (SR) aimed to investigate the impact of quercetin on mineralized dental tissues intended to be used in preventive and restorative dentistry.</div></div><div><h3>Methods</h3><div>This SR was conducted following the PRISMA-ScR statement. A comprehensive search was performed across databases for articles published up to March 2024. Eligible studies included <em>in vitro</em> and <em>in situ</em> studies and evaluating the potential therapeutic effects of quercetin on dental enamel and dentin. Data were extracted, and synthesis of study findings was conducted.</div></div><div><h3>Results</h3><div>Out of the 2322 records screened, 22 studies were included in the review. Quercetin, in solution or into dental materials increased the bond strength to enamel and dentin. Additionally, quercetin also enhanced the bond strength of enamel after bleaching. Co-administration of quercetin with fluoride prevented erosive wear and inhibited the proteolytic activity in dentin more effectively than either agent alone. Hardness and modulus of elasticity was higher in dentin treated with quercetin compared to placebo. Reduction of nanoleakage at the composite-dentin interface was reduced in the presence of quercetin as a solution or incorporated into dental adhesives.</div></div><div><h3>Conclusions</h3><div>Quercetin exhibits promising therapeutic effects on mineralized dental tissues, including remineralization and enhancement of bond strength. It shows potential as a multifunctional agent for improving the longevity and effectiveness of dental biomaterials, as well as in preventing erosion and dental caries. However, as these conclusions are largely drawn from lab-based (<em>in vitro</em>) studies, further research, including clinical trials, is needed to fully explore its therapeutic potential and applications in dentistry.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"169 ","pages":"Article 106119"},"PeriodicalIF":2.2000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of quercetin on mineralized dental tissues: A scoping review\",\"authors\":\"Gabriel Pereira Nunes , Renata de Oliveira Alves , Matheus Henrique Faccioli Ragghianti , Alexandre Henrique dos Reis-Prado , Priscila Toninatto Alves de Toledo , Tamires Passadori Martins , Ana Paula Miranda Vieira , Geórgia Rondó Peres , Cristiane Duque\",\"doi\":\"10.1016/j.archoralbio.2024.106119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This scoping review (SR) aimed to investigate the impact of quercetin on mineralized dental tissues intended to be used in preventive and restorative dentistry.</div></div><div><h3>Methods</h3><div>This SR was conducted following the PRISMA-ScR statement. A comprehensive search was performed across databases for articles published up to March 2024. Eligible studies included <em>in vitro</em> and <em>in situ</em> studies and evaluating the potential therapeutic effects of quercetin on dental enamel and dentin. Data were extracted, and synthesis of study findings was conducted.</div></div><div><h3>Results</h3><div>Out of the 2322 records screened, 22 studies were included in the review. Quercetin, in solution or into dental materials increased the bond strength to enamel and dentin. Additionally, quercetin also enhanced the bond strength of enamel after bleaching. Co-administration of quercetin with fluoride prevented erosive wear and inhibited the proteolytic activity in dentin more effectively than either agent alone. Hardness and modulus of elasticity was higher in dentin treated with quercetin compared to placebo. Reduction of nanoleakage at the composite-dentin interface was reduced in the presence of quercetin as a solution or incorporated into dental adhesives.</div></div><div><h3>Conclusions</h3><div>Quercetin exhibits promising therapeutic effects on mineralized dental tissues, including remineralization and enhancement of bond strength. It shows potential as a multifunctional agent for improving the longevity and effectiveness of dental biomaterials, as well as in preventing erosion and dental caries. However, as these conclusions are largely drawn from lab-based (<em>in vitro</em>) studies, further research, including clinical trials, is needed to fully explore its therapeutic potential and applications in dentistry.</div></div>\",\"PeriodicalId\":8288,\"journal\":{\"name\":\"Archives of oral biology\",\"volume\":\"169 \",\"pages\":\"Article 106119\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-10-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of oral biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003996924002401\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of oral biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003996924002401","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

目的本范围综述（SR）旨在研究槲皮素对拟用于预防和修复牙科的矿化牙组织的影响。在各数据库中全面检索了截至 2024 年 3 月发表的文章。符合条件的研究包括体外和原位研究，以及评估槲皮素对牙釉质和牙本质潜在治疗效果的研究。在筛选出的 2322 条记录中，有 22 项研究被纳入综述。在溶液中或牙科材料中加入槲皮素可增加与牙釉质和牙本质的粘合强度。此外，槲皮素还能增强漂白后珐琅质的粘合强度。与单独使用其中一种药剂相比，同时使用槲皮素和氟化物能更有效地防止侵蚀性磨损和抑制牙本质中的蛋白水解活性。与安慰剂相比，使用槲皮素的牙本质硬度和弹性模量更高。结论槲皮素对矿化牙组织具有良好的治疗效果，包括再矿化和增强粘接强度。槲皮素作为一种多功能制剂，在提高牙科生物材料的寿命和有效性以及预防侵蚀和龋齿方面具有潜力。不过，由于这些结论主要来自实验室（体外）研究，因此还需要进一步的研究，包括临床试验，以充分探索其在牙科中的治疗潜力和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effects of quercetin on mineralized dental tissues: A scoping review

Objective

This scoping review (SR) aimed to investigate the impact of quercetin on mineralized dental tissues intended to be used in preventive and restorative dentistry.

Methods

This SR was conducted following the PRISMA-ScR statement. A comprehensive search was performed across databases for articles published up to March 2024. Eligible studies included in vitro and in situ studies and evaluating the potential therapeutic effects of quercetin on dental enamel and dentin. Data were extracted, and synthesis of study findings was conducted.

Results

Out of the 2322 records screened, 22 studies were included in the review. Quercetin, in solution or into dental materials increased the bond strength to enamel and dentin. Additionally, quercetin also enhanced the bond strength of enamel after bleaching. Co-administration of quercetin with fluoride prevented erosive wear and inhibited the proteolytic activity in dentin more effectively than either agent alone. Hardness and modulus of elasticity was higher in dentin treated with quercetin compared to placebo. Reduction of nanoleakage at the composite-dentin interface was reduced in the presence of quercetin as a solution or incorporated into dental adhesives.

Conclusions

Quercetin exhibits promising therapeutic effects on mineralized dental tissues, including remineralization and enhancement of bond strength. It shows potential as a multifunctional agent for improving the longevity and effectiveness of dental biomaterials, as well as in preventing erosion and dental caries. However, as these conclusions are largely drawn from lab-based (in vitro) studies, further research, including clinical trials, is needed to fully explore its therapeutic potential and applications in dentistry.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry