用 FRAX 评分确定肾移植受者的骨折风险

Transplantation proceedings Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI:10.1016/j.transproceed.2024.10.009
Beyza Algul Durak, Melahat Coban, Mine Sebnem Karakan
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引用次数: 0

摘要

背景:据认为,世界卫生组织(WHO)的骨折风险评估工具(FRAX)评分可确定10年骨折风险。本研究旨在调查肾移植受者(KTRs)中用 FRAX 评分确定的主要骨质疏松性骨折(MOF)和髋部骨折(HF)值以及 FRAX 评分的实用性:这项研究的对象包括 44 名女性和 59 名男性肾移植受者以及 100 名健康对照组受试者。采用双能 X 射线吸收测量法测量骨质密度(BMD)。根据基线信息(年龄、身高、体重、股骨 BMD 和颈部 T 评分、骨折史、糖皮质激素使用情况、吸烟情况、饮酒情况以及是否患有类风湿性关节炎)计算 FRAX 分数:结果:在 KTR 中,发现 FRAX 评分 MOF 和 FRAX 评分 HF 明显升高,而 BMD 股骨 T 评分明显偏低。FRAX评分MOF和HF与肾功能检查和骨骼参数之间没有明显关系。在根据 FRAX 评分进行的接收器操作特征(ROC)分析中,MOF 的临界点被确定为≥3.4,HF 的临界点被确定为≥0.4:结论:与健康人相比,KTR 患者的 FRAX 评分 MOF 和 HF 均有所增加。FRAX评分MOF值≥3.4和HF值≥0.4表明高危患者骨折风险增加。确定的高准确率表明,在 KTR 中使用 FRAX 评分是确定骨折风险的一种有价值的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determination of Bone Fracture Risk in Kidney Transplant Recipients With FRAX Score.

Background: It is thought that the Fracture Risk Assessment Tool (FRAX) score of the World Health Organization (WHO) determines a 10-year fracture risk. This study aimed to investigate the major osteoporotic fracture (MOF) and hip fracture (HF) values determined with the FRAX score and practicality of the FRAX score in kidney transplant recipients (KTRs).

Methods: This study was conducted with 44 female and 59 male KTRs and 100 subjects in the healthy control group. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. FRAX scores were calculated from baseline information (age, height, weight, BMD of the femur and neck T score, fracture history, glucocorticoid use, smoking status, alcohol consumption, and presence of rheumatoid arthritis).

Results: In KTRs, FRAX score MOF, and FRAX score HF were found to be significantly elevated, whereas the BMD femur T score was determined to be significantly low. No significant relationship was found among the FRAX score MOF and HF and kidney function tests and bone parameters. In the receiver operating characteristic (ROC) analysis, which was performed based on the determination of the FRAX score, the cutoff point was determined as ≥ 3.4 for MOF and ≥ 0.4 for HF.

Conclusion: In KTRs, increased FRAX score MOF and HF compared with healthy individuals were determined. FRAX score MOF ≥ 3.4 and HF ≥ 0.4 values indicate high-risk patients for increased fracture risk. The high accuracy rates determined suggest that the use of the FRAX score in KTRs is a valuable method for determining fracture risk.

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