急性心肌梗死后冠状动脉微循环阻塞的机制与心脏保护策略

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-12 eCollection Date: 2024-10-01 DOI:10.31083/j.rcm2510367

Yuyu Li, Jiaqi Yu, Yuan Wang

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引用次数: 0

摘要

ST段抬高型心肌梗死患者最好接受急诊经皮冠状动脉介入治疗（PCI），而冠状动脉微血管功能障碍和阻塞（CMVO）的表现是血管造影显示心外膜前向血流缺失或减慢，导致心肌灌注效果不佳，尽管没有机械性血管阻塞。多达一半的首次接受 PCI 治疗的患者会出现 CMVO，并且与不良预后相关。本综述总结了导致 CMVO 的复杂机制，并详细阐述了在机体、组织、器官、细胞和分子水平观察到的变化。它还介绍了 CMVO 目前的诊断方法和综合治疗方法。

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Mechanism of Coronary Microcirculation Obstruction after Acute Myocardial Infarction and Cardioprotective Strategies.

ST-segment elevation myocardial infarction patients are best treated with emergency percutaneous coronary intervention (PCI), while coronary microvascular dysfunction and obstruction (CMVO) are indicated by the absence or slowing of antegrade epicardial flow on angiography, resulting in suboptimal myocardial perfusion despite the lack of mechanical vascular obstruction. CMVO occurs in up to half of patients who undergo PCI for the first time and is associated with poor outcomes. This review summarizes the complex mechanisms leading to CMVO and elaborates on the changes observed at the organism, tissue, organ, cellular, and molecular levels. It also describes the current diagnostic methods and comprehensive treatment methods for CMVO.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.