解开氧化还原密码,改善人类健康和疾病的生理研究。

IF 2.2 Q3 PHYSIOLOGY
Josh Thorley
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引用次数: 0

摘要

涉及电子转移的氧化还原反应对人体生理至关重要。然而,有缺陷的分析方法阻碍了人们在了解氧化还原代谢方面取得进展。本综述将重点介绍有望彻底改变氧化还原研究的新兴技术,从而提高我们对人类健康和疾病的认识。氧气对有氧代谢至关重要,同时也会产生活性氧(ROS),如超氧化物和过氧化氢。虽然活性氧历来被认为是有害的,但现在人们已经认识到,低浓度的活性氧是细胞信号传导的关键调节因子。ROS 与抗氧化剂之间的平衡(即氧化还原平衡)至关重要,偏差会导致氧化应激。最近的研究将有益的 "氧化应激 "与有害的 "氧化痛苦 "区分开来。先进的质谱法和高通量免疫测定等新技术提高了测量氧化还原状态和氧化损伤的准确性。这些进步对于了解氧化还原信号、半胱氨酸氧化及其对疾病的影响至关重要。展望未来,精准氧化还原医学的发展将为氧化应激相关疾病带来更好的治疗方法,并促进促进健康的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the redox code to improve physiological research in human health and disease.

Redox reactions, involving electron transfer, are critical to human physiology. However, progress in understanding redox metabolism is hindered by flawed analytical methods. This review highlights emerging techniques that promise to revolutionize redox research, enhancing our comprehension of human health and disease. Oxygen, vital for aerobic metabolism, also produces reactive oxygen species (ROS), such as superoxide and hydrogen peroxide. While historically seen as harmful, ROS at low concentrations are now recognized as key regulators of cell signaling. A balance between ROS and antioxidants, known as redox balance, is crucial, and deviations can lead to oxidative stress. Recent studies have distinguished beneficial "oxidative eustress" from harmful "oxidative distress." New techniques, such as advanced mass spectrometry and high-throughput immunoassays, offer improved accuracy in measuring redox states and oxidative damage. These advancements are pivotal for understanding redox signaling, cysteine oxidation, and their implications for disease. Looking ahead, the development of precision redox medicine could lead to better treatments for oxidative stress-related diseases and foster interventions promoting health.

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来源期刊
Physiological Reports
Physiological Reports PHYSIOLOGY-
CiteScore
4.20
自引率
4.00%
发文量
374
审稿时长
9 weeks
期刊介绍: Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.
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