Cailey Banken, Autumn N Harris, Rachel Conway, Eduardo J Benjamin, Robin Shoemaker, Darcy Adin
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引用次数: 0
摘要
一只 7 岁的雄性阉割查理士王小猎犬因继发于肌瘤性二尖瓣疾病的严重充血性心力衰竭住院治疗 12 天。在此期间,对不同天数的 6 份血清样本进行了血清生化和肾素-血管紧张素-醛固酮系统成分分析。血清氯化物浓度(从 71.6 到 103.1 mmol/L)与血管紧张素 I 浓度、醛固酮浓度、肾素活性的替代标志物以及肾上腺对血管紧张素 II 反应性的替代标志物成反比。最近的研究表明,低氯血症与狗的晚期心力衰竭有关,也与人的不良预后有关,有鉴于此,本报告中来自狗的信息支持将 RAAS 失调作为一种潜在机制进行探讨。
Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.
A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.
期刊介绍:
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.