{"title":"微针和二氧化碳激光与脂肪干细胞在面部年轻化方面的比较:随机分面研究。","authors":"Alejandra delaO-Escamilla, Jair A Valdez-Zertuche, Jorge Lara-Arias, Andrés Noyola-Pérez, Alejandra Villarreal-Martínez, Sonia Chávez-Álvarez, Adrián Cuéllar-Barboza, Rodolfo Franco-Márquez, Jorge Ocampo-Candiani, Osvaldo T Vázquez-Martínez","doi":"10.1111/ijd.17554","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Facial aging, characterized by structural decline and loss of collagen and elastin, has led to increased demand for rejuvenation treatments. Adipose-derived stem cells (ADSCs) have emerged as a promising option, but comparative studies on their application methods are limited.</p><p><strong>Objective: </strong>Our aim was to compare the efficacy of ADSC combined with microneedling or CO<sub>2</sub> laser for facial rejuvenation.</p><p><strong>Methods: </strong>Twenty-seven participants were randomized into two groups: Microneedling (MN, n = 14) or CO<sub>2</sub> laser (n = 13). Each group underwent three treatment sessions at 4-week intervals. The ADSC solution was applied to one side and the placebo to the other using a split-face design. We performed objective evaluations (UV spots, brown spots, wrinkles, texture, pores, red areas, and porphyrins) and subjective assessments, including clinical photographs, patient satisfaction scales, and histological analysis of skin biopsies.</p><p><strong>Results: </strong>The CO<sub>2</sub> laser with the ADSC group showed significantly more significant improvements in UV spots (P = 0.002) and wrinkles (P = 0.002) compared to the MN with the ADSC group. Histological analysis revealed superior elastin fibers and epidermal thickness improvements with CO<sub>2</sub> laser treatment. Patient satisfaction was higher in the CO<sub>2</sub> laser group, with 84.6% reporting complete satisfaction compared to 50% in the MN group.</p><p><strong>Conclusions: </strong>The combination of CO<sub>2</sub> laser with ADSCs demonstrated superior efficacy for facial rejuvenation compared to MN with ADSCs. This approach improved UV spots, wrinkles, skin structure, and overall patient satisfaction. Further studies with larger cohorts and extended follow-up are needed to confirm long-term efficacy.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of microneedling and CO<sub>2</sub> laser with adipose-derived stem cells for facial rejuvenation: a randomized split-face study.\",\"authors\":\"Alejandra delaO-Escamilla, Jair A Valdez-Zertuche, Jorge Lara-Arias, Andrés Noyola-Pérez, Alejandra Villarreal-Martínez, Sonia Chávez-Álvarez, Adrián Cuéllar-Barboza, Rodolfo Franco-Márquez, Jorge Ocampo-Candiani, Osvaldo T Vázquez-Martínez\",\"doi\":\"10.1111/ijd.17554\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Facial aging, characterized by structural decline and loss of collagen and elastin, has led to increased demand for rejuvenation treatments. Adipose-derived stem cells (ADSCs) have emerged as a promising option, but comparative studies on their application methods are limited.</p><p><strong>Objective: </strong>Our aim was to compare the efficacy of ADSC combined with microneedling or CO<sub>2</sub> laser for facial rejuvenation.</p><p><strong>Methods: </strong>Twenty-seven participants were randomized into two groups: Microneedling (MN, n = 14) or CO<sub>2</sub> laser (n = 13). Each group underwent three treatment sessions at 4-week intervals. The ADSC solution was applied to one side and the placebo to the other using a split-face design. We performed objective evaluations (UV spots, brown spots, wrinkles, texture, pores, red areas, and porphyrins) and subjective assessments, including clinical photographs, patient satisfaction scales, and histological analysis of skin biopsies.</p><p><strong>Results: </strong>The CO<sub>2</sub> laser with the ADSC group showed significantly more significant improvements in UV spots (P = 0.002) and wrinkles (P = 0.002) compared to the MN with the ADSC group. Histological analysis revealed superior elastin fibers and epidermal thickness improvements with CO<sub>2</sub> laser treatment. Patient satisfaction was higher in the CO<sub>2</sub> laser group, with 84.6% reporting complete satisfaction compared to 50% in the MN group.</p><p><strong>Conclusions: </strong>The combination of CO<sub>2</sub> laser with ADSCs demonstrated superior efficacy for facial rejuvenation compared to MN with ADSCs. This approach improved UV spots, wrinkles, skin structure, and overall patient satisfaction. Further studies with larger cohorts and extended follow-up are needed to confirm long-term efficacy.</p>\",\"PeriodicalId\":13950,\"journal\":{\"name\":\"International Journal of Dermatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ijd.17554\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ijd.17554","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Comparison of microneedling and CO2 laser with adipose-derived stem cells for facial rejuvenation: a randomized split-face study.
Background: Facial aging, characterized by structural decline and loss of collagen and elastin, has led to increased demand for rejuvenation treatments. Adipose-derived stem cells (ADSCs) have emerged as a promising option, but comparative studies on their application methods are limited.
Objective: Our aim was to compare the efficacy of ADSC combined with microneedling or CO2 laser for facial rejuvenation.
Methods: Twenty-seven participants were randomized into two groups: Microneedling (MN, n = 14) or CO2 laser (n = 13). Each group underwent three treatment sessions at 4-week intervals. The ADSC solution was applied to one side and the placebo to the other using a split-face design. We performed objective evaluations (UV spots, brown spots, wrinkles, texture, pores, red areas, and porphyrins) and subjective assessments, including clinical photographs, patient satisfaction scales, and histological analysis of skin biopsies.
Results: The CO2 laser with the ADSC group showed significantly more significant improvements in UV spots (P = 0.002) and wrinkles (P = 0.002) compared to the MN with the ADSC group. Histological analysis revealed superior elastin fibers and epidermal thickness improvements with CO2 laser treatment. Patient satisfaction was higher in the CO2 laser group, with 84.6% reporting complete satisfaction compared to 50% in the MN group.
Conclusions: The combination of CO2 laser with ADSCs demonstrated superior efficacy for facial rejuvenation compared to MN with ADSCs. This approach improved UV spots, wrinkles, skin structure, and overall patient satisfaction. Further studies with larger cohorts and extended follow-up are needed to confirm long-term efficacy.
期刊介绍:
Published monthly, the International Journal of Dermatology is specifically designed to provide dermatologists around the world with a regular, up-to-date source of information on all aspects of the diagnosis and management of skin diseases. Accepted articles regularly cover clinical trials; education; morphology; pharmacology and therapeutics; case reports, and reviews. Additional features include tropical medical reports, news, correspondence, proceedings and transactions, and education.
The International Journal of Dermatology is guided by a distinguished, international editorial board and emphasizes a global approach to continuing medical education for physicians and other providers of health care with a specific interest in problems relating to the skin.