微针和二氧化碳激光与脂肪干细胞在面部年轻化方面的比较:随机分面研究。

IF 3.5 4区 医学 Q1 DERMATOLOGY
Alejandra delaO-Escamilla, Jair A Valdez-Zertuche, Jorge Lara-Arias, Andrés Noyola-Pérez, Alejandra Villarreal-Martínez, Sonia Chávez-Álvarez, Adrián Cuéllar-Barboza, Rodolfo Franco-Márquez, Jorge Ocampo-Candiani, Osvaldo T Vázquez-Martínez
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引用次数: 0

摘要

背景:面部衰老的特征是结构衰退以及胶原蛋白和弹性蛋白的流失,这导致了对年轻化治疗需求的增加。脂肪源性干细胞(ADSCs)已成为一种很有前景的选择,但有关其应用方法的比较研究却很有限:我们的目的是比较脂肪干细胞与微针或二氧化碳激光联合用于面部年轻化的疗效:27名参与者被随机分为两组:微针(MN,n = 14)或二氧化碳激光(n = 13)。每组进行三次治疗,每次间隔 4 周。采用分面设计,一侧使用 ADSC 溶液,另一侧使用安慰剂。我们进行了客观评估(紫外线斑、黄褐斑、皱纹、纹理、毛孔、红色区域和卟啉)和主观评估,包括临床照片、患者满意度量表和皮肤活检组织学分析:结果:与使用 ADSC 的 MN 组相比,使用 ADSC 的 CO2 激光组在紫外线斑(P = 0.002)和皱纹(P = 0.002)方面有明显改善。组织学分析表明,二氧化碳激光治疗可改善弹性纤维和表皮厚度。二氧化碳激光组的患者满意度更高,84.6%的患者表示完全满意,而MN组的满意度仅为50%:结论:与含有 ADSCs 的 MN 相比,CO2 激光与 ADSCs 的结合在面部年轻化方面表现出更优越的疗效。这种方法改善了紫外线斑、皱纹、皮肤结构和患者的整体满意度。要确认其长期疗效,还需要进行更大规模的研究和更长时间的随访。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of microneedling and CO2 laser with adipose-derived stem cells for facial rejuvenation: a randomized split-face study.

Background: Facial aging, characterized by structural decline and loss of collagen and elastin, has led to increased demand for rejuvenation treatments. Adipose-derived stem cells (ADSCs) have emerged as a promising option, but comparative studies on their application methods are limited.

Objective: Our aim was to compare the efficacy of ADSC combined with microneedling or CO2 laser for facial rejuvenation.

Methods: Twenty-seven participants were randomized into two groups: Microneedling (MN, n = 14) or CO2 laser (n = 13). Each group underwent three treatment sessions at 4-week intervals. The ADSC solution was applied to one side and the placebo to the other using a split-face design. We performed objective evaluations (UV spots, brown spots, wrinkles, texture, pores, red areas, and porphyrins) and subjective assessments, including clinical photographs, patient satisfaction scales, and histological analysis of skin biopsies.

Results: The CO2 laser with the ADSC group showed significantly more significant improvements in UV spots (P = 0.002) and wrinkles (P = 0.002) compared to the MN with the ADSC group. Histological analysis revealed superior elastin fibers and epidermal thickness improvements with CO2 laser treatment. Patient satisfaction was higher in the CO2 laser group, with 84.6% reporting complete satisfaction compared to 50% in the MN group.

Conclusions: The combination of CO2 laser with ADSCs demonstrated superior efficacy for facial rejuvenation compared to MN with ADSCs. This approach improved UV spots, wrinkles, skin structure, and overall patient satisfaction. Further studies with larger cohorts and extended follow-up are needed to confirm long-term efficacy.

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来源期刊
CiteScore
4.70
自引率
2.80%
发文量
476
审稿时长
3 months
期刊介绍: Published monthly, the International Journal of Dermatology is specifically designed to provide dermatologists around the world with a regular, up-to-date source of information on all aspects of the diagnosis and management of skin diseases. Accepted articles regularly cover clinical trials; education; morphology; pharmacology and therapeutics; case reports, and reviews. Additional features include tropical medical reports, news, correspondence, proceedings and transactions, and education. The International Journal of Dermatology is guided by a distinguished, international editorial board and emphasizes a global approach to continuing medical education for physicians and other providers of health care with a specific interest in problems relating to the skin.
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