阿尔茨海默病可能受益于橄榄油多酚:油菜酚对淀粉样蛋白-β负荷影响的临床前证据系统综述》。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Roberta Zupo, Fabio Castellana, Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Roberta Tardugno, Nicola Cicero, Filomena Corbo, Pasquale Crupi, Rodolfo Sardone, Maria Lisa Clodoveo
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引用次数: 0

摘要

背景:地中海饮食可增强认知功能并延缓阿尔茨海默病(AD)的进展。考虑到作为地中海饮食模式主要成分的特级初榨橄榄油(EVOO)生物酚的抗炎和神经保护作用,我们进行了一项系统性综述,研究特级初榨橄榄油(EVOO)中的油黄质(OC)对临床前阿尔茨海默病模型中淀粉样蛋白-β(Aβ)负担的影响:方法:通过六个电子数据库检索文献,检索期至 2023 年 2 月。根据纳入标准对检索到的 52 篇文章进行筛选,结果发现有 7 篇临床前报告通过受影响模型中的 Aβ 负荷或清除率评估了补充 OC 的饮食对注意力缺失症轨迹的影响。使用 SYRCLE 的 RoB 工具对报告进行了偏倚风险评估。研究方案已在 PROSPERO.Results 上注册:病例对照设计优于病例交叉设计,地域分布为统一的美洲。研究对象多为 5xFAD 小鼠,其他为 TgSwDI 或野生型 C57BL/6 小鼠模型。与对照组相比,我们发现 OC 在减少海马实质和微血管中的 Aβ 负荷方面发挥了作用。在富含 OC 的临床前模型中,通过血脑屏障清除脑内 Aβ 的能力增强,代谢和行为参数也得到了显著改善。总体而言,偏倚风险适中:临床前数据表明,地中海膳食中的乙烯基氧化物中的 OC 有助于减轻注意力缺失症中 Aβ 的负担;但是,还需要进一步的证据来证实这种生物酚的功效,并加强推测的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load.

Background: Mediterranean diet may enhance cognitive function and delay the progression of Alzheimer's disease (AD). We conducted a systematic review to investigate the effect of oleocanthal (OC) from extra-virgin olive oil (EVOO) on amyloid-β (Aβ) burden in preclinical models of AD, considering the anti-inflammatory and neuroprotective effects of EVOO biophenols, which are key components of the Mediterranean dietary model.

Methods: The literature was searched through six electronic databases until February 2023. Screening of 52 retrieved articles for inclusion criteria resulted in 7 preclinical reports evaluating the effect of an OC-supplemented diet on AD trajectories by means of Aβ load or clearance in affected models. Reports were appraised for risk of bias using the SYRCLE's RoB tool. A protocol was registered on PROSPERO.

Results: Case control prevailed over the case-crossover design, and the geographical distribution was uniformly American. The study population mostly included 5xFAD, otherwise TgSwDI or wild-type C57BL/6 mouse models. We found a role of OC in reducing Aβ load in the hippocampal parenchyma and microvessels compared with controls. An increased cerebral clearance of Aβ through the bloodbrain barrier and a substantial improvement in metabolic and behavioral parameters were also reported in preclinical models under an OC-enriched diet. The risk of bias was shown to be moderate overall.

Conclusion: Preclinical data are promising about the effects of OC from the Mediterranean diet's EVOO in relieving the burden of Aβ in AD; however, further evidence is needed to corroborate the efficacy of this biophenol and strengthen the speculated causal pathway.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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