石婴:图文并茂的文章,从 25 块博物馆石碑中汲取灵感。

IF 1.6 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Lucas L. Boer, Andreas Wasserscheid, Eduard Winter, Laurens de Rooy, Annelieke N. Schepens-Franke, Giovanni Magno, Alice Cusan, Helga Rehder, Jana Behunova, Anke Scharrer, Nick Lobé, Philipp Peloschek, Roelof-Jan Oostra, Susanne G. Kircher
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引用次数: 0

摘要

背景:结石症(或称 "结石宝宝")是一种极为罕见的临床现象,医学文献中记载的病例不到 350 例。当晚期宫外孕停止发育并经历碎石过程时,就会出现这种情况,并可能形成具有胎儿样形态的钙化肿块。通常情况下,碎石会在数十年内保持无症状,但偶尔也会引发急性症状,需要进行医疗干预。然而,这些实体主要是在放射检查或尸检中偶然发现的:本文全面概述了 25 例碎石症病例,包括来自欧洲多家医学博物馆的未报告病例。在可行的情况下,我们进行了额外的放射成像检查,以提高诊断的清晰度。此外,本文还从更广阔的历史视角和详细的病因学框架出发,阐述了碎石形成的生理和病理机制。结石现象证明了人体的复杂性和神秘性:通过对大量病例的整理和研究,本综述为了解碎石的临床意义提供了宝贵的见解。此外,它还强调了对此类罕见病症进行持续研究和细致记录的必要性,从而有助于加深对特殊现象的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Stone Babies: A Pictorial Essay With Insights From 25 Museal Lithopaedions

Stone Babies: A Pictorial Essay With Insights From 25 Museal Lithopaedions

Background

Lithopaedion, or “stone baby,” represents an exceptionally rare clinical phenomenon with fewer than 350 documented cases existing in the medical literature. This condition arises when an advanced extrauterine pregnancy ceases its developmental trajectory and undergoes a lithification process, potentially resulting in a calcified mass with fetal-like morphology. Typically, lithopaedions remain asymptomatic for decades, but may occasionally elicit acute symptoms necessitating medical intervention. However, predominantly, these entities are incidental findings discovered during radiological examinations or autopsies.

Results

In this article, we present a comprehensive overview of 25 lithopaedion cases, including unreported cases from several European medical museums. When feasible, additional radiological imaging was conducted to enhance diagnostic clarity. Furthermore, this article situates lithopaedions within a broader historical perspective and a detailed etiopathogenetic framework, elucidating the physiological and pathological mechanisms contributing to their formation. The phenomenon of lithopaedion is a testimony to the complex and often enigmatic nature of the human body.

Conclusions

By compiling and scrutinizing a substantial number of cases, this review offers valuable insights into the clinical implications of lithopaedions. Furthermore, it highlights the necessity for ongoing research and meticulous documentation of rare medical conditions like this, in order to contribute to a deeper understanding of extraordinary phenomena.

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来源期刊
Birth Defects Research
Birth Defects Research Medicine-Embryology
CiteScore
3.60
自引率
9.50%
发文量
153
期刊介绍: The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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