脂肪组织驻留的 iNKT 细胞中的脂质积累导致了炎症表型。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Adipocyte Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI:10.1080/21623945.2024.2421750
Imogen Morris, Frank Vrieling, Annemieke Bouwman, Rinke Stienstra, Eric Kalkhoven
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引用次数: 0

摘要

脂肪细胞和免疫细胞之间的相互交流对于维持脂肪组织(AT)的最佳功能至关重要。其中,脂肪细胞直接与不变NKT细胞(iNKT细胞)相互作用,进而分泌各种细胞因子。在肥胖症中观察到的富含脂质的微环境会使这种由脂肪细胞驱动的细胞因子输出偏向更具炎症性的输出。然而,富含脂质的微环境是否也会直接影响 iNKT 细胞还不得而知。在这里,我们发现从 AT 分离出来的小鼠原代 iNKT 细胞能在脂滴(LDs)中积聚脂质,比肝脏和脾脏驻留的 iNKT 细胞积聚得更多。此外,富含脂质的微环境会增加促炎细胞因子 IFNγ 的产生。除了脂肪细胞介导的间接提示外,iNKT 细胞还能直接对环境中的脂质变化做出反应,从而支持其作为营养传感器的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype.

Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete various cytokines. A lipid-rich microenvironment, as observed in obesity, skews this adipocyte-driven cytokine output towards a more inflammatory output. Whether a lipid-rich microenvironment also affects iNKT cells directly, however, is unknown. Here, we show that primary mouse iNKT cells isolated from AT can accumulate lipids in lipid droplets (LDs), more so than liver- and spleen-resident iNKT cells. Furthermore, a lipid-rich microenvironment increased the production of the proinflammatory cytokine IFNγ. Next, to an indirect, adipocyte-mediated cue, iNKT cells can directly respond to environmental lipid changes, supporting a potential role as nutrient sensors.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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