在碱促进下,N-炔基-2-噁唑烷酮的串联开环/闭环可简化 2-噁唑啉的合成。

IF 2.9 3区 化学 Q1 CHEMISTRY, ORGANIC
Xingyuan Ye, Peng Bao, Yan Pan, Han Xiao, Qiuwen Li, Guangke He
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引用次数: 0

摘要

该研究描述了一种由 K2CO3 促进的 N-alkynyl-2-oxazolidinones 串联开环/闭环反应,无需柱层析分离即可得到产率为 42-99% 的 2-恶唑啉类化合物。这种操作简单的反应在环境条件下进行,无需过渡金属催化剂和外部氧化剂,可用于生物活性化合物的后期官能化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Base-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones enables facile synthesis of 2-oxazolines.

A K2CO3-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones has been described, affording 2-oxazolines in 42-99% yields without column chromatography isolation. This operationally simple reaction proceeds under ambient conditions without a transition-metal catalyst and an external oxidant and can be applied for the late-stage functionalization of biologically active compounds.

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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: The international home of synthetic, physical and biomolecular organic chemistry.
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