在碱促进下，N-炔基-2-噁唑烷酮的串联开环/闭环可简化 2-噁唑啉的合成。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-30 DOI:10.1039/d4ob01561d

Xingyuan Ye , Peng Bao , Yan Pan , Han Xiao , Qiuwen Li , Guangke He

引用次数: 0

摘要

该研究描述了一种由 K2CO3 促进的 N-alkynyl-2-oxazolidinones 串联开环/闭环反应，无需柱层析分离即可得到产率为 42-99% 的 2-恶唑啉类化合物。这种操作简单的反应在环境条件下进行，无需过渡金属催化剂和外部氧化剂，可用于生物活性化合物的后期官能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Base-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones enables facile synthesis of 2-oxazolines†

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Base-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones enables facile synthesis of 2-oxazolines†

A K₂CO₃-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones has been described, affording 2-oxazolines in 42–99% yields without column chromatography isolation. This operationally simple reaction proceeds under ambient conditions without a transition-metal catalyst and an external oxidant and can be applied for the late-stage functionalization of biologically active compounds.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.