碳酸二甲酯作为有机改性剂在亚/超临界流体色谱法中对新型精神活性物质进行对映体分离的优势

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2024-10-31 DOI:10.1016/j.aca.2024.343380

Denisa Folprechtová , Elisabeth Seibert , Martin G. Schmid , Květa Kalíková

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引用次数: 0

摘要

背景与传统的液相色谱技术相比，亚/超临界流体色谱法使用二氧化碳作为流动相的主要成分，因此被认为是一种更环保的分离技术。通常在二氧化碳中加入有机助溶剂，以增加流动相的洗脱强度。因此，测试绿色助溶剂在分离方法中的适用性，并将其纳入常用的流动相组分中具有重要意义。结果使用一组来自不同组别的新型精神活性物质，对绿色溶剂碳酸二甲酯作为助溶剂在亚/超临界流体色谱中进行对映体分离的适用性进行了全面研究。实验在多糖基色谱柱上进行。为了成功地对这些化合物进行对映体分离，必须使用碱性或混合流动相添加剂。研究结果清楚地表明，碳酸二甲酯是亚/超临界流体色谱法中多糖基色谱柱上进行对映体分离的合适助溶剂，在某些情况下甚至超过了甲醇和丙-2-醇等常用助溶剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advantages of dimethyl carbonate as organic modifier for enantioseparation of novel psychoactive substances in sub/supercritical fluid chromatography

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Advantages of dimethyl carbonate as organic modifier for enantioseparation of novel psychoactive substances in sub/supercritical fluid chromatography

Background

Sub/supercritical fluid chromatography is regarded as a greener separation technique due to the use of carbon dioxide as the main component of the mobile phase compared to conventional liquid chromatography techniques. Organic co-solvents are usually added to carbon dioxide to increase elution strength of the mobile phase. Therefore, it is of great importance to test applicability of green co-solvents in separation methods and to include them among commonly used mobile phase components.

Results

A comprehensive study of the suitability of green solvent dimethyl carbonate as a co-solvent for enantioseparation in sub/supercritical fluid chromatography was conducted with a set of novel psychoactive substances from various groups. The experiments were performed on polysaccharide-based columns. For successful enantioseparation of these compounds, the presence of basic or mixed mobile phase additives was essential. The obtained results clearly show that dimethyl carbonate is a suitable co-solvent for enantioseparation on polysaccharide-based columns in sub/supercritical fluid chromatography and in some cases surpasses commonly used co-solvents as methanol and propan-2-ol.

Significance

The use of more sustainable co-solvents, such as dimethyl carbonate, instead of conventional ones to carbon dioxide presents a greener approach to analytical applications and reduces the overall environmental impact of analytical processes.

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.