用于颅颌面骨再生的个性化生物陶瓷移植物

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Ana Beatriz G. de Carvalho, Maedeh Rahimnejad, Rodrigo L. M. S. Oliveira, Prabaha Sikder, Guilherme S. F. A. Saavedra, Sarit B. Bhaduri, Debby Gawlitta, Jos Malda, Darnell Kaigler, Eliandra S. Trichês, Marco C. Bottino
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引用次数: 0

摘要

颅颌面骨缺损的重建在临床上仍具有挑战性。迄今为止,自体移植物被认为是黄金标准,但却存在严重缺陷。这些缺点促使最近的颅颌面骨重建研究将重点放在采用不同材料和制造技术的合成移植物上。在各种制造方法中,增材制造(AM)已显示出巨大的临床潜力。增材制造技术可根据计算机辅助设计构建具有个性化几何形状的三维(3D)物体。这些逐层叠加的三维生物材料结构可通过引导细胞迁移/增殖、成骨和血管生成来支持骨形成。此外,这些结构还可以在新骨组织形成的同时降解,使其成为理想的合成移植物。本综述将深入探讨通过三维打印技术获得的生物陶瓷移植物/支架在个性化颅颌面骨重建方面的主要进展。在这方面,将讨论与临床相关的主题,如陶瓷基生物材料、移植物/支架特性(宏观/微观特征)、基于材料挤压的三维打印,以及设计个性化生物陶瓷移植物的逐步工作流程。重要的是,我们强调了体外模型,并对研究这些生物陶瓷及其对细胞反应/行为的影响时所报道的信号通路进行了深入探讨。最后,我们总结了用于颅颌面骨再生的个性化生物陶瓷的临床潜力和转化机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Personalized bioceramic grafts for craniomaxillofacial bone regeneration

Personalized bioceramic grafts for craniomaxillofacial bone regeneration

The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitantly with the new bone tissue formation, making them ideal as synthetic grafts. This review delves into the key advances of bioceramic grafts/scaffolds obtained by 3D printing for personalized craniomaxillofacial bone reconstruction. In this regard, clinically relevant topics such as ceramic-based biomaterials, graft/scaffold characteristics (macro/micro-features), material extrusion-based 3D printing, and the step-by-step workflow to engineer personalized bioceramic grafts are discussed. Importantly, in vitro models are highlighted in conjunction with a thorough examination of the signaling pathways reported when investigating these bioceramics and their effect on cellular response/behavior. Lastly, we summarize the clinical potential and translation opportunities of personalized bioceramics for craniomaxillofacial bone regeneration.

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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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