Claire M. Corbett , Samantha L. Bozarth , Elizabeth A. West
{"title":"性别和发情周期对行动-结果或然性的影响","authors":"Claire M. Corbett , Samantha L. Bozarth , Elizabeth A. West","doi":"10.1016/j.bbr.2024.115317","DOIUrl":null,"url":null,"abstract":"<div><div>Goal-directed and habitual-like behaviors are both necessary to efficiently and effectively navigate the environment. A dysregulation between these behaviors can lead to an overreliance on habitual-like behaviors and may contribute to symptoms experienced in some neuropsychiatric disorders such as substance use disorder. One behavioral task used to evaluate goal-directed and habitual-like behavior is an action-outcome task, contingency degradation, where an action (i.e., lever press) is degraded by decoupling the receipt of a reward from the action. However, little is known about how male and female rats and females across the estrous cycle respond during contingency degradation training and extinction testing. Here, we investigated how the variable of sex and estrous cycle influences contingency degradation training and extinction testing and the correlation between baseline anxiety-like behaviors and performance on contingency degradation extinction testing in adult male and female Long-Evans rats. We found that both males and females learned the contingency degradation task. However, during extinction testing, males respond more to the contingent lever than the non-contingent lever while females do not differ in their responses on the non-contingent and contingent levers. Lower baseline anxiety-like behavior predicted better performance on the contingency degradation test in males, but not females. Next, when we examined performance during extinction testing in females based on their estrous cycle stage on test day, we found that females in the proestrus and estrus stages of the estrous cycle do not differ in their responses on the non-contingent and contingent levers, while females in the metestrus and diestrus stages of the estrous cycle respond more on the contingent lever than the non-contingent lever on the extinction test day, similar to male rats. Our findings indicate that the estrous cycle influences how female rats respond during contingency degradation extinction testing that is dependent on their estrous cycle stage.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115317"},"PeriodicalIF":2.6000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of sex and estrous cycle on action-outcome contingencies\",\"authors\":\"Claire M. Corbett , Samantha L. Bozarth , Elizabeth A. West\",\"doi\":\"10.1016/j.bbr.2024.115317\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Goal-directed and habitual-like behaviors are both necessary to efficiently and effectively navigate the environment. A dysregulation between these behaviors can lead to an overreliance on habitual-like behaviors and may contribute to symptoms experienced in some neuropsychiatric disorders such as substance use disorder. One behavioral task used to evaluate goal-directed and habitual-like behavior is an action-outcome task, contingency degradation, where an action (i.e., lever press) is degraded by decoupling the receipt of a reward from the action. However, little is known about how male and female rats and females across the estrous cycle respond during contingency degradation training and extinction testing. Here, we investigated how the variable of sex and estrous cycle influences contingency degradation training and extinction testing and the correlation between baseline anxiety-like behaviors and performance on contingency degradation extinction testing in adult male and female Long-Evans rats. We found that both males and females learned the contingency degradation task. However, during extinction testing, males respond more to the contingent lever than the non-contingent lever while females do not differ in their responses on the non-contingent and contingent levers. Lower baseline anxiety-like behavior predicted better performance on the contingency degradation test in males, but not females. Next, when we examined performance during extinction testing in females based on their estrous cycle stage on test day, we found that females in the proestrus and estrus stages of the estrous cycle do not differ in their responses on the non-contingent and contingent levers, while females in the metestrus and diestrus stages of the estrous cycle respond more on the contingent lever than the non-contingent lever on the extinction test day, similar to male rats. Our findings indicate that the estrous cycle influences how female rats respond during contingency degradation extinction testing that is dependent on their estrous cycle stage.</div></div>\",\"PeriodicalId\":8823,\"journal\":{\"name\":\"Behavioural Brain Research\",\"volume\":\"477 \",\"pages\":\"Article 115317\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Behavioural Brain Research\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S016643282400473X\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioural Brain Research","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016643282400473X","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
Effects of sex and estrous cycle on action-outcome contingencies
Goal-directed and habitual-like behaviors are both necessary to efficiently and effectively navigate the environment. A dysregulation between these behaviors can lead to an overreliance on habitual-like behaviors and may contribute to symptoms experienced in some neuropsychiatric disorders such as substance use disorder. One behavioral task used to evaluate goal-directed and habitual-like behavior is an action-outcome task, contingency degradation, where an action (i.e., lever press) is degraded by decoupling the receipt of a reward from the action. However, little is known about how male and female rats and females across the estrous cycle respond during contingency degradation training and extinction testing. Here, we investigated how the variable of sex and estrous cycle influences contingency degradation training and extinction testing and the correlation between baseline anxiety-like behaviors and performance on contingency degradation extinction testing in adult male and female Long-Evans rats. We found that both males and females learned the contingency degradation task. However, during extinction testing, males respond more to the contingent lever than the non-contingent lever while females do not differ in their responses on the non-contingent and contingent levers. Lower baseline anxiety-like behavior predicted better performance on the contingency degradation test in males, but not females. Next, when we examined performance during extinction testing in females based on their estrous cycle stage on test day, we found that females in the proestrus and estrus stages of the estrous cycle do not differ in their responses on the non-contingent and contingent levers, while females in the metestrus and diestrus stages of the estrous cycle respond more on the contingent lever than the non-contingent lever on the extinction test day, similar to male rats. Our findings indicate that the estrous cycle influences how female rats respond during contingency degradation extinction testing that is dependent on their estrous cycle stage.
期刊介绍:
Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.