Persistent primary vitreous: A report on 2 rare pediatric cases

Persistence of the fetal vasculature (PFV) is a rare ocular malformation of unknown origin, characterized by a spectrum of complex presentations with varying functional prognoses. We reported the cases of 2 male patients: a 3-month-old infant and a 4-year-old child. A thorough examination of their eyes, often requiring general anesthesia, is essential for diagnosis. The malformation can manifest in mild forms without visual impact or associated anomalies, as well as severe forms involving multiple ocular structures and systemic syndromes. A comprehensive pediatric examination is recommended to identify any associated conditions. Treatment is personalized and typically includes early, targeted surgical and medical interventions to optimize outcomes.

The cases highlight the importance of early diagnosis and comprehensive evaluation in managing persistence of the fetal vasculature, as timely intervention can significantly improve visual outcomes.