用于化学和生物医学传感的空芯抗谐振光纤

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2024-10-24 DOI:10.1016/j.sbsr.2024.100701

Ruijiao Miao , Xin Zhang , Jinping Zhang , Shuqin Li , Pu Wang , Xiu-Hong Wang

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引用次数: 0

摘要

中空芯反谐振光纤（HC-ARF）为打破大功率传输和高效光波导领域的瓶颈提供了解决方案。除传输光波外，HC-ARF 还能在单根光纤中协同结合微流控与光学技术，实现前所未有的光路长度，这是平面光流控配置难以实现的。HC-ARF 具有严格的光局限性、宽传输带和低传输损耗等独特特性，能够以较低的样品消耗实现较高的传感性能，从而超越传统的光学检测方法。在这篇综述中，我们全面介绍了用于无标记分子传感的 HC-ARF。我们介绍了 HC-ARF 的光传播机制和最新结构，以及化学和生物医学传感领域的最新进展，主要包括气体、液体、DNA 和蛋白质传感器，以及基于外泌体的液体活检和癌细胞检测。最后，还讨论了 HC-ARF 在传感应用中面临的挑战和前景。

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Hollow-core anti-resonant optical fibers for chemical and biomedical sensing

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Hollow-core anti-resonant optical fibers for chemical and biomedical sensing

Hollow-core anti-resonant optical fiber (HC-ARF) provides solutions for breaking the bottlenecks in areas of high-power transmission and high-efficiency optical waveguide. Other than transporting light wave, HC-ARFs can synergistically combine microfluidics and optics in a single fiber with unprecedented light path length not readily achievable by planar optofluidic configurations. The unique features of strict light confinement, wide transmission band and low transmission loss of HC-ARFs enable high sensing performance with low sample consumption, outcompeting conventional optical assays. In this review, we provide a comprehensive overview of HC-ARFs for label-free molecular sensing. We deliver information on the light propagation mechanism and state-of-the-art structures of HC-ARFs, as well as recent progress in chemical and biomedical sensing mainly covering gas, liquid, DNA and protein sensors along with exosome-based liquid biopsy and cancer cell detection. At the end, challenges and prospects of HC-ARF for sensing applications are discussed.

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.