初榨椰子油通过减少哮喘豚鼠体内转化生长因子 β 的表达，防止气道重塑并恢复气管松弛反应性

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2024-11-01 DOI:10.1016/j.jff.2024.106544

Luiz Henrique César Vasconcelos , Maria da Conceição Correia Silva , Alana Cristina Costa , Giuliana Amanda de Oliveira , Iara Leão Luna de Souza , Rubens da Silva Araújo , Adriano Francisco Alves , Fabiana de Andrade Cavalcante , Bagnólia Araújo da Silva

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引用次数: 0

摘要

哮喘是一种慢性炎症性疾病，许多患者对药物疗法没有适当的反应。因此，初榨椰子油（VCO）可以作为一种替代疗法。豚鼠被分为对照组（Ctrl）、慢性过敏性肺部炎症组（Asth）、使用地塞米松治疗的哮喘组（Asth + dexa）和补充了 VCO 的哮喘组（Asth + VCO4）。受试动物对卵清蛋白过敏并受到卵清蛋白的挑战。花生四烯酸（AA）诱导的松弛作用在 Asth 中受损，而 VCO 可阻止这一下降（p = 0.0004），这表明 VCO 可形成松弛性前列腺素或减少半胱氨酰-白三烯。此外，VCO 还阻止了 TGF-β 对 Asth 中 β 受体/BKCa 通路可能的负向调节（p = 0.0073）。最后，Masson 三色染色显示哮喘患者的气道重塑，免疫组化显示哮喘患者肺中 TGF-β 的表达增加（p < 0.0001），VCO 和地塞米松可阻止这种表达（p < 0.0001），因此 VCO 可能是一种治疗哮喘的药物。

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Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig

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Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig

Asthma is a chronic inflammatory disease with many patients failing to respond appropriately to pharmacotherapy. Thus, virgin coconut oil (VCO) can be an alternative therapy. Guinea pigs were divided into control (Ctrl), chronic allergic lung inflammation (Asth), Asth treated with dexamethasone (Asth + dexa), and Asth supplemented with VCO (Asth + VCO4). The tested animals were sensitized and challenged with ovalbumin. Relaxation induced by arachidonic acid (AA) was impaired in Asth, and this reduction was prevented by VCO (p = 0.0004), indicating formation of relaxing prostanoids, or the decrease of cysteinyl-leukotrienes by VCO. Furthermore, a possible negative modulation of β receptors/BK_Ca pathway by TGF–β in Asth was prevented by VCO (p = 0.0073). Finally, in Asth, Masson’s trichrome staining revealed airway remodeling and immunohistochemistry showed increased TGF-β expression in the lungs of Asth (p < 0.0001)), which was prevented by VCO and dexamethasone (p < 0.0001), concluding VCO as a possible agent against asthma.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.