用于线粒体成像和癌症协同治疗的香豆素基 ACQ-AIE 转换光敏剂

IF 4.6 2区 化学 Q2 CHEMISTRY, PHYSICAL
Lu Zhang, Fangyuan Chai, Haibo Dong, Yali Bao, Ke Yan, Shuang Min, Yuke Yao, Shun Li, Yi Liu, Tao Gao*, Jianglin Wang* and Yujiao Liu*, 
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引用次数: 0

摘要

传统的荧光分子大多具有荧光量子产率高、稳定性好、结构可调节性强等优点,但它们表现出聚集引起荧光淬灭的特性,限制了它们在水溶液或固体中的应用。聚集诱导发射(AIE)材料在凝聚态下的优异发光特性和光敏潜力使其在科研领域受到广泛关注,因此如何调控传统聚集淬灭(ACQ)荧光团向聚集诱导发射荧光团的转化是一项非常具有挑战性的工作。本研究以传统的香豆素荧光团为基质。在共轭三苯胺 AIE 基团后,通过烷基链连接三苯基膦阳离子,得到一种具有优异 AIE 特性、水溶性、线粒体绿光成像、化疗和光动力治疗功能的分子探针 NCTPP。据我们所知,通过 ACQ-AIE 转换法赋予香豆素荧光分子光敏性尚属首次。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Coumarin-Based ACQ-AIE Conversion Photosensitizer for Mitochondrial Imaging and Synergistic Cancer Therapy

Coumarin-Based ACQ-AIE Conversion Photosensitizer for Mitochondrial Imaging and Synergistic Cancer Therapy

Most of the traditional fluorescent molecules have the advantages of high fluorescence quantum yield, good stability, and excellent structural adjustability, but they exhibit the characteristics of fluorescence quenching caused by aggregation, which restricts their application in aqueous solutions or solids. The excellent luminescence properties and photosensitive potential of aggregation-induced emission (AIE) materials in a condensed state have made them widely concerned in the scientific research field, so it is very challenging to regulate the transformation of traditional aggregation-caused quenching (ACQ) fluorophores into AIE fluorophores. In this study, the traditional coumarin fluorophore was used as a matrix. After conjugating the triphenylamine AIE group, the triphenylphosphine cation was linked through the alkyl chain to obtain a molecular probe NCTPP with excellent AIE characteristic, water solubility, mitochondrial green light imaging, chemotherapy and photodynamic therapy capabilities. As far as we know, it was the first time that the photosensitivity of coumarin fluorescent molecules was imparted by the ACQ-AIE conversion method.

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来源期刊
The Journal of Physical Chemistry Letters
The Journal of Physical Chemistry Letters CHEMISTRY, PHYSICAL-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
9.60
自引率
7.00%
发文量
1519
审稿时长
1.6 months
期刊介绍: The Journal of Physical Chemistry (JPC) Letters is devoted to reporting new and original experimental and theoretical basic research of interest to physical chemists, biophysical chemists, chemical physicists, physicists, material scientists, and engineers. An important criterion for acceptance is that the paper reports a significant scientific advance and/or physical insight such that rapid publication is essential. Two issues of JPC Letters are published each month.
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