累积的社会经济地位风险与中年黑人血清神经丝轻链水平的大幅上升有关。

Man-Kit Lei, Steven R H Beach, Ronald L Simons, Michelle M Mielke
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引用次数: 0

摘要

背景:本研究考察了累积社会经济地位(SES)风险与血清神经丝蛋白轻链(NfL)水平之间的纵向关系,以更好地了解社会因素与神经变性生物标志物之间的关联:我们使用了家庭与社区健康研究(FACHS)的数据,在两次波次(2008 年和 2019 年)收集了 254 名美国黑人(43 名男性和 211 名女性)的社会心理和血液数据。在每个波次对血液样本进行血清 NfL 浓度分析。回归分析和混合效应模型检验了累积 SES 风险与血清 NfL 之间的关系,控制了协变量并评估了时间效应:结果:利用 11 年的纵向数据,血清 NfL 水平随年龄增长而增加。基线时累积的 SES 风险较高与 11 年随访时血清 NfL 升高相关,并预测 NfL 水平会有更大的升高。在临床上,NfL是轴突损伤和神经退行性变的敏感生物标志物,常用于检测阿尔茨海默病(AD)、多发性硬化症和其他神经退行性疾病的早期和临床前阶段:我们的研究结果表明,黑人成年人所面临的累积性社会经济风险可能会导致 NfL 水平升高,从而显示出潜在的早期神经退行性疾病。鉴于NfL在检测神经退行性病变过程中的既定作用,这些发现强调了加强社会安全网和社会联系的干预措施对于增进大脑健康和降低神经退行性病变风险的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cumulative Socioeconomic Status Risk is Associated with Greater Increase in Serum Neurofilament Light Chain Levels Among Middle-Aged Black Adults.

Background: This study examined the longitudinal relationship between cumulative socioeconomic status (SES) risk and serum neurofilament light chain (NfL) levels to better understand the association between social factors and a biomarker of neurodegeneration.

Methods: We used data from the Family and Community Health Study (FACHS), collecting psychosocial and blood data at two waves (2008) and (2019) from 254 Black Americans (43 males and 211 females). Blood samples were analyzed at each wave for serum NfL concentrations. Regression analysis and mixed-effect modeling examined relationships between cumulative SES risk and serum NfL, controlling for covariates and assessing time effects.

Results: Utilizing 11-year longitudinal data, serum NfL levels increased with age. Higher cumulative SES risk at baseline correlated with elevated serum NfL at the 11-year follow-up and predicted a greater increase in NfL levels. Clinically, NfL is a sensitive biomarker for axonal injury and neurodegeneration, commonly used to detect early and preclinical stages of conditions such as Alzheimer's disease (AD), multiple sclerosis, and other neurodegenerative disorders.

Conclusions: Our results suggest that exposure to cumulative SES risk among Black adults may contribute to elevated levels of NfL, indicating potential early neurodegeneration. Given the established role of NfL in detecting neurodegenerative processes, these findings underscore the importance of interventions that bolster social safety nets and social connectedness to enhance brain health and mitigate neurodegenerative risks.

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