戒酒期间酒精使用障碍患者骨转换标志物与渴求减少的关系:探索骨脑轴的作用

IF 3 Q2 SUBSTANCE ABUSE
Hsuan Megan Tsao, Ming-Chyi Huang, Tung-Hsia Liu, Hu-Ming Chang, Ren-Hua Chung, Hsiang-Wei Kuo, Andrew C. H. Chen, Rong-Sen Yang, Yu-Li Liu
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引用次数: 0

摘要

背景:酒精使用障碍(AUD)与骨转换失衡和心理症状有关,但骨骼和大脑之间的关系仍不清楚。本研究分析了 AUD 患者在戒酒 2 周前和戒酒 2 周后血清中骨形成标志物--1 型胶原蛋白 N 端前肽(P1NP)和骨吸收标志物--I 型胶原蛋白 C 端端肽(CTX-1)的水平,并研究了它们与心理症状的相关性:方法:招募了 90 名 AUD 患者和 117 名健康对照者。方法:招募了 90 名 AUD 患者和 117 名健康对照者,采用酶联免疫吸附测定法检测 P1NP 和 CTX-1 水平。宾州酒精渴求量表(PACS)、贝克抑郁量表(BDI)和贝克焦虑量表(BAI)分别在基线、戒断第一周和第二周对 AUD 组进行了评估:结果:AUD 组的 CTX-1 基线水平、CTX-1/P1NP 和 P1NP/CTX-1 比率均高于对照组。在为期两周的戒断过程中,PACS、BDI 和 BAI 评分均有显著下降。P1NP(P在两周的戒酒过程中,骨代谢转向骨形成增加和骨吸收减少。戒酒期间骨转换标志物的改善与渴求评分的降低之间的相关性支持了骨-脑轴的概念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of bone turnover markers and craving reduction in patients with alcohol use disorder during withdrawal: Exploring the role of bone-brain axis

Association of bone turnover markers and craving reduction in patients with alcohol use disorder during withdrawal: Exploring the role of bone-brain axis

Background

Alcohol use disorder (AUD) is associated with imbalanced bone turnover and psychological symptoms, but the relationship between bone and brain remains unclear. The study analyzed serum levels of a bone formation marker, procollagen type 1 N-terminal propeptide (P1NP), and bone resorption marker, C-terminal telopeptide of type I collagen (CTX-1), in AUD patients before and after 2 weeks of alcohol withdrawal and investigated their correlation with psychological symptoms.

Methods

Ninety patients with AUD and 117 healthy controls were recruited. P1NP and CTX-1 levels were measured using Enzyme-Linked Immunosorbent Assay. The Penn Alcohol Craving Scale (PACS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were assessed in the AUD group at baseline, week 1, and week 2 of withdrawal.

Results

Baseline CTX-1 levels, along with the CTX-1/P1NP and P1NP/CTX-1 ratio, were higher in the AUD group than controls. Over the 2-week withdrawal, PACS, BDI, and BAI scores demonstrated significant reductions. P1NP (p < 0.001) and P1NP/CTX-1 ratio increased (p < 0.001), while CTX-1/P1NP ratio decreased (p < 0.001), indicating a propensity toward bone formation. Univariate analysis revealed that reductions in PACS, BDI, and BAI scores during withdrawal correlated with increased P1NP levels and decreased CTX-1/P1NP ratios. However, multivariate analysis indicated that only PACS score reductions correlated with these changes.

Conclusions

Bone metabolism shifted toward increased bone formation and decreased bone resorption during 2-week alcohol withdrawal. The correlation between improvements in bone turnover markers and reduction in craving scores during withdrawal supports the concept of the bone-brain axis.

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