健康人与年龄有关的免疫特征:一项原创研究、系统回顾和荟萃分析。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Syuan-Ting Chang, Yi-Fang Chuang, Ai-Hsien Li, Yang-Teng Fan, Man-Ru Liao, I-Yu Chen, Ruo-Wei Hung, Tienyu Owen Yang, Yen-Ling Chiu
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引用次数: 0

摘要

背景:循环外周免疫系统是确定个人免疫状态最方便的方法。由于种种原因,虽然以往的研究已经探讨了年龄的关键影响,但大多数单项研究并未对免疫衰老进行系统分析,这使得为有效的免疫监测建立年龄相关免疫特征参考范围的可能性变得复杂。为了填补这一空白,本研究对一组健康人进行了分析,以建立特定年龄的健康循环免疫特征参考范围,并进行了系统回顾和荟萃分析,以验证研究结果并建立可推广的免疫细胞参考范围:我们的研究共招募了 363 名健康的台湾成年人(中位年龄 42 岁 [IQR:30,62],年龄范围 21 至 87 岁,男性占 43.3%),其中 40 岁以下 158 人,40 至 64 岁 127 人,64 岁以上 78 人。在适应性和先天性免疫细胞亚群中都观察到了与年龄相关的显著变化。CD8 + T 细胞减少,CD4/CD8 比率增加,NK 细胞显著增加。CD4 + T 细胞受衰老的影响较小,而 CD8 + T 细胞随着年龄的增长,CD28 表达明显减少,CD31 表达增加。在 CD4 + 和 CD8 + T 细胞的幼稚亚群和记忆亚群中观察到明显的反向趋势。建立了台湾健康成年人免疫细胞亚群的详细参考范围。一项系统性综述纳入了 7,425 名成年人,对 12 项符合条件的研究进行的荟萃分析证实了我们在台湾的研究结果,从而提高了研究的普遍性:结论:通过系统综述和荟萃分析,结合之前的研究和原始数据,我们强调并量化了老年人和年轻人之间显著的免疫特征差异。外周免疫细胞亚群的性别和年龄特异性参考范围可作为对各种衰老相关疾病进行有效免疫监测的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis.

Background: The circulatory peripheral immune system is the most convenient approach for determining an individual's immune status. Due to various reasons, while previous studies have addressed the critical impact of age, most individual studies did not analyze immunosenescence in a systemic manner, which complicates the possibility of building a reference range for age-dependent immune profiles for effective immune monitoring. To address this gap, this study analyzed a group of healthy individuals to establish age-specific reference ranges of the healthy circulatory immune profile, and a systematic review and meta-analysis were conducted to validate the findings and create generalizable immune cell reference ranges.

Results: Our study recruited a total of 363 healthy Taiwanese adults (median age 42 years [IQR 30, 62], age range 21 to 87 years, 43.3% male), including 158 under 40 years old, 127 between 40-64 years old, and 78 over 64 years old. Significant age-related alterations were observed in both adaptive and innate immune cell subsets. CD8 + T cells decreased and CD4/CD8 ratio increased, with notable increases in NK cells. CD4 + T cells were less impacted by aging, while CD8 + T cells significantly lost CD28 and increased CD31 expression with age. A clear reverse trend in naïve and memory subsets of CD4 + and CD8 + T cells was observed. Detailed reference ranges for immune cell subsets in healthy Taiwanese adults were established. A systematic review included 7,425 adults and a meta-analysis of 12 eligible studies confirmed our findings in Taiwan, enhancing generalizability.

Conclusions: Combined with previous studies and original data through a systematic review and meta-analysis, we highlighted and quantified significant immune profile differences between older and younger individuals. The sex and age-specific reference ranges for peripheral immune cell subsets can serve as a basis for effective immune monitoring of various aging-related illnesses.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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