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引用次数: 0
摘要
我们对大脑回路运行和失调的了解，已经迅速超过了我们干预和恢复它们的能力。开发能够精确连接任何脑区和脑回路的技术，可以将诊断与治疗干预结合起来，加快个性化脑部医疗的进程。经颅超声刺激（TUS）是应对这一挑战的一种前景广阔的非侵入性解决方案，它具有病灶精确性和可扩展性。通过利用压力波对脑组织的生物力学作用，经颅超声刺激可对大脑皮层和深层区域的分布式回路进行多部位定向神经调控。在这篇论文中，我们探讨了 TUS 可以对功能障碍区域进行功能测试和改造的新证据，它可以有效地充当大脑的搜索和救援工具。我们将明确 TUS 所面临的挑战和机遇，因为它正朝着更高的目标精确度以及与先进的大脑监测和介入技术相结合的方向发展。最后，我们提出了 TUS 从研究工具发展为临床验证的脑疾病治疗方法的路线图。
The future of transcranial ultrasound as a precision brain interface.
Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene and restore them. Developing technologies that can precisely interface with any brain region and circuit may combine diagnostics with therapeutic intervention, expediting personalised brain medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution to this challenge, offering focal precision and scalability. By exploiting the biomechanics of pressure waves on brain tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in the cortex and deeper areas alike. In this Essay, we explore the emergent evidence that TUS can functionally test and modify dysfunctional regions, effectively serving as a search and rescue tool for the brain. We define the challenges and opportunities faced by TUS as it moves towards greater target precision and integration with advanced brain monitoring and interventional technology. Finally, we propose a roadmap for the evolution of TUS as it progresses from a research tool to a clinically validated therapeutic for brain disorders.
期刊介绍：
PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions.
The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public.
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