益生菌牙膏和普通牙膏对成年正畸患者牙龈健康和牙菌斑水平的影响--一项开放标签随机对照试验。

IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

International Orthodontics Pub Date : 2024-10-30 DOI:10.1016/j.ortho.2024.100938

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引用次数: 0

摘要

导言：益生菌是一种活的微生物，有可能通过调节口腔微生物群来影响口腔健康，并为牙龈和牙齿疾病的预防提供了一种很有前景的方法。这种方法尤其适用于正畸患者，因为他们更容易出现牙龈炎症和牙菌斑堆积。这项随机对照研究旨在比较益生菌牙膏和普通牙膏对正畸患者牙龈健康和牙菌斑水平的影响：参与者招募时间为 2024 年 6 月 4 日至 2024 年 7 月 15 日，年龄在 18 至 50 岁之间。他们没有精神/身体残疾、颅面疾病、珐琅质/牙齿发育不良，也没有服用影响牙菌斑堆积的药物。参与者通过电脑程序和密封信封被随机分为两组：A组（对照组）使用普通牙膏（高露洁），每天两次，为期四周；B组使用含有副干酪乳杆菌的益生菌牙膏，每天两次，为期四周。所有参与者都接受了标准的口腔卫生指导。主要结果是四周内牙龈出血指数（GBI）和牙菌斑指数（PI）的平均变化。这是一项开放标签试验。只有评估者是盲人，评估标准是客观的：最终纳入并分析了 44 名参与者，每组 22 人。干预后，益生菌组的牙龈评分中位数[0.12（IQR 0.09，0.16）]明显低于对照组[0.15（IQR 0.10，0.18）]，P 值为 0.041（95% CI：0.009-0.18）。然而，两组之间的斑块评分没有明显差异[益生菌：20.0（IQR 18.0，21.0）vs 对照组：21.0（IQR 19.0，22.0），P=0.15]。无重大不良事件或副作用报告：结论：在本试验条件下，与普通牙膏相比，益生菌牙膏仅能显著改善正畸患者的牙龈出血指数：试验注册：ClinicalTrial.gov (NCT06473792)。

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Effect of probiotic toothpaste and regular toothpaste on gingival health and plaque levels of adult orthodontic patients – An open label randomized controlled trial

Introduction

Probiotics are living micro-organisms that are likely to influence oral health by modulating the oral microbiota and offer a promising preventive approach to gum and dental disease. This approach is particularly relevant for orthodontic patients, who are more susceptible to gingival inflammation and plaque accumulation. The aim of this randomized controlled study was to compare the effects of a probiotic toothpaste versus a regular toothpaste on gingival health and plaque levels in orthodontic patients.

Methods

Participants were recruited between 4 June 2024 and 15 July 2024, and were aged between 18 and 50 years. They did not suffer from mental/physical disabilities, craniofacial disorders, enamel/tooth dysplasia and were not taking medication affecting plaque build-up. Participants were randomized in two groups using a computer programme and sealed envelopes: the group A (control) used an ordinary toothpaste (Colgate) twice a day for four weeks, the group B used a probiotic toothpaste containing Lactobacillus paracasei twice a day for four weeks. Standard oral hygiene instructions were given to all participants. The primary outcome was the mean change in gingival bleeding index (GBI) and plaque index (PI) over four weeks. This was an open-label trial. Only the evaluator was blinded and the evaluation criteria were objective.

Results

Forty-four participants, 22 in each group, were finally included and analysed. After the intervention, the probiotic group had a significantly lower median gingival score [0.12 (IQR 0.09, 0.16)] than the control group [0.15 (IQR 0.10, 0.18)], with a p-value of 0.041 (95% CI: 0.009–0.18). However, there was no significant difference in plaque scores between the two groups [Probiotic: 20.0 (IQR 18.0, 21.0) vs. control: 21.0 (IQR 19.0, 22.0), P = 0.15]. No significant adverse events or side effects were reported.

Conclusion

Under the conditions of this trial, the probiotic toothpaste only significantly improved the gingival bleeding index in orthodontic patients compared to regular toothpaste.

Trial Registration

ClinicalTrial.gov (NCT06473792).

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来源期刊

International Orthodontics DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.50

自引率

13.30%

发文量

审稿时长

26 days

期刊介绍： Une revue de référence dans le domaine de orthodontie et des disciplines frontières Your reference in dentofacial orthopedics International Orthodontics adresse aux orthodontistes, aux dentistes, aux stomatologistes, aux chirurgiens maxillo-faciaux et aux plasticiens de la face, ainsi quà leurs assistant(e)s. International Orthodontics is addressed to orthodontists, dentists, stomatologists, maxillofacial surgeons and facial plastic surgeons, as well as their assistants.