评估猫细菌和病毒感染后炎症反应的多样性

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES
Songul Erhan, Bengu Bilgic, Ezgi Ergen, Mert Erek, Elif Ergul Ekiz, Mukaddes Ozcan, Mehmet Erman Or, Banu Dokuzeylul, Erdal Matur
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引用次数: 0

摘要

背景:了解猫细菌和病毒感染时炎症反应的性质对于准确控制感染至关重要。本研究旨在调查猫细菌和病毒感染时炎症反应的多样性,以了解它们在这些感染的病理生理学中的作用:研究纳入了 75 只猫咪。评估分为三组:健康对照组、细菌感染组(支气管肺炎、胃肠道和泌尿道感染)和病毒感染组(21 只感染猫冠状病毒[FCoV],3 只感染猫白血病病毒[FeLV],1 只感染猫卡里西病毒),每组 25 只。从患病动物和健康动物采集的血液样本中评估了白细胞总数和差值、C 反应蛋白 (CRP)、转化生长因子 beta (TGF-β)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、白细胞介素-1 beta (IL-1β) 和白细胞介素-10 (IL-10) 的浓度:感染猫血清中 TNF-α、IL-1β 和 IL-10 的浓度在统计学上没有明显差异(分别为 p = 0.996、p = 0.160 和 p = 0.930)。与健康对照组相比,病毒感染组的血清 TGF-β 浓度有所降低(p = 0.001)。相反,与健康对照组和病毒感染组相比,支气管肺炎、胃肠道感染和尿路感染猫的白细胞计数、IL-6 和 CRP 浓度均有所增加(分别为 p = 0.001、p = 0.001 和 p = 0.001):这项研究揭示了细菌感染和病毒感染在猫的炎症反应方式上的显著差异,相关数据无疑将有助于猫科传染病的管理和控制,并促进新型治疗策略的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections.

Background: Understanding the nature of inflammatory responses in cats with bacterial and viral infections is essential for accurately managing the infection. This study aimed to investigate the diversities of inflammatory responses between bacterial and viral infections in cats to figure out their role in the pathophysiology of these infections.

Methods: Seventy-five owned cats were included in the study. The evaluations were performed based on three groups: healthy control, bacterial infection group (those with bronchopneumonia and gastrointestinal tract and urinary tract infections) and viral infection group (21 with feline coronavirus [FCoV], 3 with feline leukaemia virus [FeLV] and 1 with feline calicivirus), each containing 25 individuals. Total and differential leukocyte counts, C-reactive protein (CRP), transforming growth factor beta (TGF-β), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10) concentrations were assessed in the blood samples collected from sick and healthy animals.

Results: No statistically significant difference was noted in serum TNF-α, IL-1β and IL-10 concentrations of the infected cats (p = 0.996, p = 0.160 and p = 0.930, respectively). Serum TGF-β concentration in the viral infection group was reduced compared to the healthy control (p = 0.001). In contrast, WBC count and IL-6 and CRP concentrations were increased in the cats with bronchopneumonia, gastrointestinal tract infections and urinary tract infections compared to the healthy control and viral infection groups (p = 0.001, p = 0.001 and p = 0.001, respectively).

Conclusion: This study revealed significant differences between bacterial and viral infections regarding the fashion of inflammatory responses in cats, and the relevant data will undoubtedly contribute to the management and control of feline infectious diseases, rendering the development of novel therapeutic strategies.

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来源期刊
Veterinary Medicine and Science
Veterinary Medicine and Science Veterinary-General Veterinary
CiteScore
3.00
自引率
0.00%
发文量
296
期刊介绍: Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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