格林巴利综合征后的震颤

IF 2.5 Q2 CLINICAL NEUROLOGY
Tremor and Other Hyperkinetic Movements Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI:10.5334/tohm.906
José Fidel Baizabal-Carvallo, Carlos Manuel Cortés, Marlene Alonso-Juarez, Robert Fekete
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引用次数: 0

摘要

背景:神经性震颤发生于外周神经系统受损时。吉兰-巴雷综合征(Guillain-Barré syndrome,GBS)会在神经发炎后引起急性瘫痪,有时会导致长期残疾。目前还不清楚 GBS 后震颤的发生率和严重程度:我们旨在评估 GBS 后震颤的频率和特征:我们招募了 18 名在一家二级医疗中心接受治疗的 GBS 患者,时间跨度为 4 年。采用法恩-托洛萨-马林震颤评分量表(FTM-TRS)进行评估。我们将这些特征与一组未经治疗的本质性震颤(ET)患者进行了比较:患者中有 13 名男性和 5 名女性,评估时的平均年龄(S.D. )为 41.5 ± 14.0 岁,GBS 发病时的平均年龄(S.D. )为 40.2 ± 13.7 岁。没有患者在 GBS 发病前有震颤病史。16例(89%)患者出现上肢震颤,35.5%的患者 FTM-TRS 评分≥10 分。震颤多为运动性、抽搐性、低振幅震颤,FTM-TRS总分为(10.94 ± 11.84)分。与 ET 患者相比,GBS 震颤患者更年轻,在 FTM-TRS 的所有分量表中的得分也更低(所有比较的 P 值均小于 0.05)。在多变量线性回归分析中,"住院天数 "与 FTM-TRS 总分呈正相关(P = 0.001):结论:GBS 患者常见震颤。与 ET 患者相比,震颤程度较轻,但会增加对功能的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tremor Following Guillain Barré Syndrome.

Background: Neuropathic tremor occurs with damage to the peripheral nervous system. Guillain-Barré syndrome (GBS) causes acute paralysis following nerve inflammation sometimes resulting in long-term disability. It is unclear how frequent and severe tremor is following GBS.

Objectives: We aimed to assess the frequency and features of tremor following GBS.

Methods: We enrolled 18 patients with GBS treated in a secondary care center within a 4-year period. Evaluations were done with the Fahn-Tolosa-Marin tremor rating scale (FTM-TRS). We compared these features with a cohort of consecutive patients with untreated essential tremor (ET).

Results: There were 13 males and 5 females with a mean age at evaluation (S.D.) of 41.5 ± 14.0 years and at GBS onset of 40.2 ± 13.7. No patient had history of tremor before GBS. Upper limb tremor was identified in 16 (89%) cases, 35.5% of patients had FTM-TRS score ≥10 points. Tremor was mostly kinetic, jerky with low amplitude with a total score of 10.94 ± 11.84 in the FTM-TRS. Compared with patients with ET, those with GBS-tremor were younger and had lower scores in all subscales of the FTM-TRS (P value < 0.05 for all comparisons). In a multivariate linear regression analysis "days of hospitalization" had a positive association with the total FTM-TRS score (P = 0.001).

Conclusions: Tremor was common following GBS. This tremor is mild compared with patients with ET, but adds functional impact.

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来源期刊
CiteScore
4.00
自引率
4.50%
发文量
31
审稿时长
6 weeks
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