Yuna Koyama, Henning Tiemeier, Pei Huang, Shi Yu Chan, Mioko Sudo, Yena Kyeong, Michael Meaney, Peipei Setoh, Ai Peng Tan
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T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.</p><p><strong>Results: </strong>Harsh parenting was associated with more severe externalizing problems in girls (<i>β</i> = 0.24, 95% CI 0.08-0.40) but not boys (<i>p</i><sub>int</sub> = 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).</p><p><strong>Conclusions: </strong>Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. 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引用次数: 0
摘要
背景:幼儿期父母的严厉教养与后代的不良行为结果有关。由于纵向神经影像学数据稀缺,很少有研究探讨这种关联的神经生物学基础,重点关注人体内的变异性。本研究利用纵向神经影像学数据,考察了严厉的养育方式、日后的行为问题以及杏仁核体积和杏仁核静态功能连接(RSFC)特征的发展轨迹之间的时间关联:该研究是在新加坡健康成长(GUSTO)队列中进行的。研究收集了4.5岁、6岁、7.5岁和10.5岁儿童的T1加权扫描数据(296名儿童,642次扫描)和静息功能扫描数据(256名儿童,509次扫描)。研究提取了杏仁核体积以及杏仁核与六个在情绪调节中起主导作用的大脑区域之间的RSFC。4.5 岁时的严厉养育和 10.5 岁时的儿童行为问题则通过家长报告问卷进行评估。研究采用线性回归和线性混合模型:在女孩中,严厉的养育方式与更严重的外化问题有关(β = 0.24,95% CI 0.08-0.40),但与男孩无关(pint = 0.07)。在整个样本中,严厉的养育方式与杏仁核-ACC、杏仁核-OFC和杏仁核-DLPFC RSFC的发展轨迹相关。此外,杏仁核-ACC RSFC的发育轨迹对女孩的严厉养育-外化问题关联起到了中介作用(间接效应=0.06,95% CI 0.01-0.14):结论:幼儿期父母的严厉教养与杏仁核神经回路的发育和行为问题有关。杏仁核-ACC RSFC的发展轨迹是连接严厉养育和女孩外化问题的潜在神经机制。
Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems.
Background: Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.
Methods: The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.
Results: Harsh parenting was associated with more severe externalizing problems in girls (β = 0.24, 95% CI 0.08-0.40) but not boys (pint = 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).
Conclusions: Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. The developmental trajectory of amygdala-ACC RSFC is a potential neural mechanism linking harsh parenting and externalizing problems in girls.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.