糖尿病周围神经病变患者的 MDA、SOD、TAOC、MNCV、SNCV 和 TSS 评分分析。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.1515/biol-2022-0945
Yukun Jia, Yan Li
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引用次数: 0

摘要

目的 探讨中药包加红光疗法和硫辛酸治疗糖尿病周围神经病变(DPN)患者的评分对丙二醛(MDA)、红细胞超氧化物歧化酶(SOD)、总抗氧化能力(TAOC)、运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)和多伦多临床评分系统(TSS)的影响。研究人员选取了 108 名在医院住院治疗的 DPN 患者,采用随机数字表法将其分为两组。对照组(CG)54 名患者接受常规硫辛酸治疗,实验组(EG)54 名患者在 CG 的基础上接受 TCMP 加红光治疗。比较两组患者治疗前和治疗后的 MDA、SOD、TAOC、MNCV、SNCV 和 TSS 评分。治疗前,两组的氧化指标、神经传导速度和症状评分差异无统计学意义(P>0.05)。治疗后,EG 的 MDA 低于 CG,差异有统计学意义(P < 0.05)。EG 的 SOD 和 TAOC 均高于 CG,差异有统计学意义(P < 0.05)。EG 正中神经、腓总神经和胫神经的 MNCV 和 SNCV 均显著高于 CG(P < 0.05)。EG 的 TSS 评分低于 CG,差异有统计学意义(P < 0.05)。硫辛酸加TCMP和红光疗法治疗DPN患者可改善疾病症状和体征,促进运动和感觉传导速度的恢复,优化机体氧化指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy.

To explore the impact of score in patients with diabetes peripheral neuropathy (DPN) treated with traditional Chinese medicine package (TCMP) plus red light therapy and lipoic acid on malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), total antioxidant capacity (TAOC), motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV), and Toronto Clinical Scoring System (TSS). A total of 108 patients with DPN hospitalized in the hospital were chosen and divided into groups with the random number table. In the control group (CG) 54 patients were treated with conventional lipoic acid, and 54 patients in the experimental group (EG) accepted TCMP plus red light on the basis of the CG. The MDA, SOD, TAOC, MNCV, SNCV, and TSS scores before treatment and after treatment were compared between the two groups. Before treatment, there was no statistically significant difference in the levels of oxidation indicators, nerve conduction velocity, and symptom scores between the two groups (P > 0.05). After treatment, the MDA in the EG was lower than that in the CG, with a statistical significance difference (P < 0.05). The SOD and TAOC in the EG were higher than those in the CG, and the difference was statistically significant (P < 0.05). The MNCV and SNCV of median nerve, common peroneal nerve, and tibial nerve in the EG were significantly higher than those in the CG (P < 0.05). The TSS score of the EG was lower than that of the CG, and the difference was statistically significant (P < 0.05). The treatment of patients with DPN with lipoic acid plus TCMP and red light therapy can improve the symptoms and signs of disease, promote the recovery of motor and sensory conduction velocity, and optimize the body oxidation indicators.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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